A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing
Abstract Novel modalities such as PROTAC and RNAi have the ability to inadvertently alter the abundance of endogenous proteins. Currently available in vitro secondary pharmacology assays, which evaluate off-target binding or activity of small molecules, do not fully assess the off-target effects of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/bceb4a3a9b72451bb8dd1f5b780cc4d7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|