Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization

Ricardo Alexandre Stock, Gustavo Brustollin, Rafael André Mergener, Elcio Luiz Bonamigo Medical School of the University of the West of Santa Catarina (Universidade do Oeste de Santa Catarina – UNOESC), Joaçaba Campus, State of Santa Catarina, BrazilCorrespondence: Ri...

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Autores principales:	Stock RA, Brustollin G, Mergener RA, Bonamigo EL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	corneal diseases cornea keratometry efficacy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bcec5578effd4477a181c2070a96f124
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spelling	oai:doaj.org-article:bcec5578effd4477a181c2070a96f1242021-12-02T08:29:30ZEfficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization1177-5483https://doaj.org/article/bcec5578effd4477a181c2070a96f1242020-06-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-standard-and-accelerated-10-minutes-corneal-crosslinking-i-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ricardo Alexandre Stock, Gustavo Brustollin, Rafael André Mergener, Elcio Luiz Bonamigo Medical School of the University of the West of Santa Catarina (Universidade do Oeste de Santa Catarina – UNOESC), Joaçaba Campus, State of Santa Catarina, BrazilCorrespondence: Ricardo Alexandre Stock Email ricardostockreal@gmail.comPurpose: To evaluate whether Accelerated CXL for 10 minutes is as effective as standard CXL for 30 minutes for the treatment of progressive keratoconus.Patients and Methods: Eighty-two eyes of 62 patients with keratometry examinations performed before and 6 months after surgery were studied. A total of 39 eyes underwent standard CXL with UVA irradiation of 3 mW/cm2 for 30 minutes and 32 eyes underwent Accelerated CXL UVA irradiation of 9 mW/cm2 for 10 minutes. The eyes of all patients had corneal thicknesses of at least 450 microns (400 microns after epithelium removal).Results: The means of the keratometry measurements in the preoperative period for the eyes subjected to standard CXL were 46.27 dioptres (D) on the flat axis (K1) and 48.93 D on the steep axis (K2). Postoperatively, K1 was 46.21 D and K2 was 48.97 D, a difference without statistical significance (p = 0.47 and p = 0.48, respectively). In the Accelerated CXL protocol, the preoperative measurements were 44.55 D and 46.19 D for K1 and K2, respectively. In the postoperative period, K1 was 43.37 D, and K2 was 46.64 D (p = 0.38 and p = 0.27, respectively). In the standard group, the mean maximum keratometry (Kmax) preoperatively was 55.87 D, with no statistical significance (p = 0.29). In the preoperative period, the Kmax of the Accelerated group was 51.15 D, with no statistical significance (p = 0.32).Conclusion: Based on the keratometry results, the accelerated protocol was as effective as the standard protocol for keratoconus stabilization.Keywords: corneal diseases, cornea, keratometry, efficacyStock RABrustollin GMergener RABonamigo ELDove Medical Pressarticlecorneal diseasescorneakeratometryefficacyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1735-1740 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal diseases cornea keratometry efficacy Ophthalmology RE1-994
spellingShingle	corneal diseases cornea keratometry efficacy Ophthalmology RE1-994 Stock RA Brustollin G Mergener RA Bonamigo EL Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization
description	Ricardo Alexandre Stock, Gustavo Brustollin, Rafael André Mergener, Elcio Luiz Bonamigo Medical School of the University of the West of Santa Catarina (Universidade do Oeste de Santa Catarina – UNOESC), Joaçaba Campus, State of Santa Catarina, BrazilCorrespondence: Ricardo Alexandre Stock Email ricardostockreal@gmail.comPurpose: To evaluate whether Accelerated CXL for 10 minutes is as effective as standard CXL for 30 minutes for the treatment of progressive keratoconus.Patients and Methods: Eighty-two eyes of 62 patients with keratometry examinations performed before and 6 months after surgery were studied. A total of 39 eyes underwent standard CXL with UVA irradiation of 3 mW/cm2 for 30 minutes and 32 eyes underwent Accelerated CXL UVA irradiation of 9 mW/cm2 for 10 minutes. The eyes of all patients had corneal thicknesses of at least 450 microns (400 microns after epithelium removal).Results: The means of the keratometry measurements in the preoperative period for the eyes subjected to standard CXL were 46.27 dioptres (D) on the flat axis (K1) and 48.93 D on the steep axis (K2). Postoperatively, K1 was 46.21 D and K2 was 48.97 D, a difference without statistical significance (p = 0.47 and p = 0.48, respectively). In the Accelerated CXL protocol, the preoperative measurements were 44.55 D and 46.19 D for K1 and K2, respectively. In the postoperative period, K1 was 43.37 D, and K2 was 46.64 D (p = 0.38 and p = 0.27, respectively). In the standard group, the mean maximum keratometry (Kmax) preoperatively was 55.87 D, with no statistical significance (p = 0.29). In the preoperative period, the Kmax of the Accelerated group was 51.15 D, with no statistical significance (p = 0.32).Conclusion: Based on the keratometry results, the accelerated protocol was as effective as the standard protocol for keratoconus stabilization.Keywords: corneal diseases, cornea, keratometry, efficacy
format	article
author	Stock RA Brustollin G Mergener RA Bonamigo EL
author_facet	Stock RA Brustollin G Mergener RA Bonamigo EL
author_sort	Stock RA
title	Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization
title_short	Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization
title_full	Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization
title_fullStr	Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization
title_full_unstemmed	Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization
title_sort	efficacy of standard and accelerated (10 minutes) corneal crosslinking in keratoconus stabilization
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bcec5578effd4477a181c2070a96f124
work_keys_str_mv	AT stockra efficacyofstandardandaccelerated10minutescornealcrosslinkinginkeratoconusstabilization AT brustolling efficacyofstandardandaccelerated10minutescornealcrosslinkinginkeratoconusstabilization AT mergenerra efficacyofstandardandaccelerated10minutescornealcrosslinkinginkeratoconusstabilization AT bonamigoel efficacyofstandardandaccelerated10minutescornealcrosslinkinginkeratoconusstabilization
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Efficacy of Standard and Accelerated (10 Minutes) Corneal Crosslinking in Keratoconus Stabilization

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