Oxidative Stress in Preterm Newborns

Preterm babies are highly susceptible to oxidative stress (OS) due to an imbalance between the oxidant and antioxidant systems. The generation of free radicals (FR) induces oxidative damage to multiple body organs and systems. OS is the main factor responsible for the development of typical prematur...

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Autores principales:	Chiara Lembo, Giuseppe Buonocore, Serafina Perrone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxidative stress free radicals newborn infants prematurity antioxidants biomarkers Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/bcef9837b63c4f0dba07c94f9ccce4e5
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spelling	oai:doaj.org-article:bcef9837b63c4f0dba07c94f9ccce4e52021-11-25T16:25:47ZOxidative Stress in Preterm Newborns10.3390/antiox101116722076-3921https://doaj.org/article/bcef9837b63c4f0dba07c94f9ccce4e52021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1672https://doaj.org/toc/2076-3921Preterm babies are highly susceptible to oxidative stress (OS) due to an imbalance between the oxidant and antioxidant systems. The generation of free radicals (FR) induces oxidative damage to multiple body organs and systems. OS is the main factor responsible for the development of typical premature infant diseases, such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, periventricular leukomalacia, kidney damage, eryptosis, and also respiratory distress syndrome and patent ductus arteriosus. Many biomarkers have been detected to early identify newborns at risk of developing a free radical-mediated disease and to investigate new antioxidant strategies. This review reports the current knowledge on OS in the preterm newborns and the newest findings concerning the use of OS biomarkers as diagnostic tools, as well as in implementing antioxidant therapeutic strategies for the prevention and treatment of these diseases and their sequelae.Chiara LemboGiuseppe BuonocoreSerafina PerroneMDPI AGarticleoxidative stressfree radicalsnewborn infantsprematurityantioxidantsbiomarkersTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1672, p 1672 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress free radicals newborn infants prematurity antioxidants biomarkers Therapeutics. Pharmacology RM1-950
spellingShingle	oxidative stress free radicals newborn infants prematurity antioxidants biomarkers Therapeutics. Pharmacology RM1-950 Chiara Lembo Giuseppe Buonocore Serafina Perrone Oxidative Stress in Preterm Newborns
description	Preterm babies are highly susceptible to oxidative stress (OS) due to an imbalance between the oxidant and antioxidant systems. The generation of free radicals (FR) induces oxidative damage to multiple body organs and systems. OS is the main factor responsible for the development of typical premature infant diseases, such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, intraventricular hemorrhage, periventricular leukomalacia, kidney damage, eryptosis, and also respiratory distress syndrome and patent ductus arteriosus. Many biomarkers have been detected to early identify newborns at risk of developing a free radical-mediated disease and to investigate new antioxidant strategies. This review reports the current knowledge on OS in the preterm newborns and the newest findings concerning the use of OS biomarkers as diagnostic tools, as well as in implementing antioxidant therapeutic strategies for the prevention and treatment of these diseases and their sequelae.
format	article
author	Chiara Lembo Giuseppe Buonocore Serafina Perrone
author_facet	Chiara Lembo Giuseppe Buonocore Serafina Perrone
author_sort	Chiara Lembo
title	Oxidative Stress in Preterm Newborns
title_short	Oxidative Stress in Preterm Newborns
title_full	Oxidative Stress in Preterm Newborns
title_fullStr	Oxidative Stress in Preterm Newborns
title_full_unstemmed	Oxidative Stress in Preterm Newborns
title_sort	oxidative stress in preterm newborns
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bcef9837b63c4f0dba07c94f9ccce4e5
work_keys_str_mv	AT chiaralembo oxidativestressinpretermnewborns AT giuseppebuonocore oxidativestressinpretermnewborns AT serafinaperrone oxidativestressinpretermnewborns
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Oxidative Stress in Preterm Newborns

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