Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.

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Detalles Bibliográficos
Autores principales: Marilia Rita Pinzone, D. Jake VanBelzen, Sam Weissman, Maria Paola Bertuccio, LaMont Cannon, Emmanuele Venanzi-Rullo, Stephen Migueles, R. Brad Jones, Talia Mota, Sarah B. Joseph, Kevin Groen, Alexander O. Pasternak, Wei-Ting Hwang, Brad Sherman, Anastasios Vourekas, Giuseppe Nunnari, Una O’Doherty
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/bcf0eb263eba47799a2cae2421234886
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Descripción
Sumario:How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.

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