Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.

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Autores principales:	Marilia Rita Pinzone, D. Jake VanBelzen, Sam Weissman, Maria Paola Bertuccio, LaMont Cannon, Emmanuele Venanzi-Rullo, Stephen Migueles, R. Brad Jones, Talia Mota, Sarah B. Joseph, Kevin Groen, Alexander O. Pasternak, Wei-Ting Hwang, Brad Sherman, Anastasios Vourekas, Giuseppe Nunnari, Una O’Doherty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bcf0eb263eba47799a2cae2421234886
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spelling	oai:doaj.org-article:bcf0eb263eba47799a2cae24212348862021-12-02T14:38:45ZLongitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion10.1038/s41467-019-08431-72041-1723https://doaj.org/article/bcf0eb263eba47799a2cae24212348862019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08431-7https://doaj.org/toc/2041-1723How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.Marilia Rita PinzoneD. Jake VanBelzenSam WeissmanMaria Paola BertuccioLaMont CannonEmmanuele Venanzi-RulloStephen MiguelesR. Brad JonesTalia MotaSarah B. JosephKevin GroenAlexander O. PasternakWei-Ting HwangBrad ShermanAnastasios VourekasGiuseppe NunnariUna O’DohertyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marilia Rita Pinzone D. Jake VanBelzen Sam Weissman Maria Paola Bertuccio LaMont Cannon Emmanuele Venanzi-Rullo Stephen Migueles R. Brad Jones Talia Mota Sarah B. Joseph Kevin Groen Alexander O. Pasternak Wei-Ting Hwang Brad Sherman Anastasios Vourekas Giuseppe Nunnari Una O’Doherty Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
description	How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.
format	article
author	Marilia Rita Pinzone D. Jake VanBelzen Sam Weissman Maria Paola Bertuccio LaMont Cannon Emmanuele Venanzi-Rullo Stephen Migueles R. Brad Jones Talia Mota Sarah B. Joseph Kevin Groen Alexander O. Pasternak Wei-Ting Hwang Brad Sherman Anastasios Vourekas Giuseppe Nunnari Una O’Doherty
author_facet	Marilia Rita Pinzone D. Jake VanBelzen Sam Weissman Maria Paola Bertuccio LaMont Cannon Emmanuele Venanzi-Rullo Stephen Migueles R. Brad Jones Talia Mota Sarah B. Joseph Kevin Groen Alexander O. Pasternak Wei-Ting Hwang Brad Sherman Anastasios Vourekas Giuseppe Nunnari Una O’Doherty
author_sort	Marilia Rita Pinzone
title	Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
title_short	Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
title_full	Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
title_fullStr	Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
title_full_unstemmed	Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
title_sort	longitudinal hiv sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bcf0eb263eba47799a2cae2421234886
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Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

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