Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus
Mayaro virus (MAYV) is a neglected arthropod-borne virus found in the Americas. MAYV infection results in Mayaro fever, a non-lethal debilitating disease characterized by a strong inflammatory response affecting the joints and muscles. MAYV was once considered endemic to forested areas in Brazil but...
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2021
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oai:doaj.org-article:bcf1744c16904acfa9e9f16270792f762021-11-25T19:12:25ZEvaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus10.3390/v131121231999-4915https://doaj.org/article/bcf1744c16904acfa9e9f16270792f762021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2123https://doaj.org/toc/1999-4915Mayaro virus (MAYV) is a neglected arthropod-borne virus found in the Americas. MAYV infection results in Mayaro fever, a non-lethal debilitating disease characterized by a strong inflammatory response affecting the joints and muscles. MAYV was once considered endemic to forested areas in Brazil but has managed to adapt and spread to urban regions using new vectors, such as <i>Aedes aegypti</i>, and has the potential to cause serious epidemics in the future. Currently, there are no vaccines or specific treatments against MAYV. In this study, the antiviral activity of a series of synthetic cyclic ketones were evaluated for the first time against MAYV. Twenty-four compounds were screened in a cell viability assay, and eight were selected for further evaluation. Effective concentration (EC<sub>50</sub>) and selectivity index (SI) were calculated and compound 9-(5-(4-chlorophenyl]furan-2-yl)-3,6-dimethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2))-dione (9) (EC<sub>50</sub> = 21.5 µmol·L<sup>−1</sup>, SI = 15.8) was selected for mechanism of action assays. The substance was able to reduce viral activity by approximately 70% in both pre-treatment and post-treatment assays.Luciana S. FernandesMilene L. da SilvaRoberto S. DiasMarcel S. da S. LucindoÍtalo E. P. da SilvaCynthia C. SilvaRóbson R. TeixeiraSérgio O. de PaulaMDPI AGarticlemayaro viruscyclic ketonesxanthenodionesantiviralsarbovirusMicrobiologyQR1-502ENViruses, Vol 13, Iss 2123, p 2123 (2021) |
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DOAJ |
| collection |
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| language |
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| topic |
mayaro virus cyclic ketones xanthenodiones antivirals arbovirus Microbiology QR1-502 |
| spellingShingle |
mayaro virus cyclic ketones xanthenodiones antivirals arbovirus Microbiology QR1-502 Luciana S. Fernandes Milene L. da Silva Roberto S. Dias Marcel S. da S. Lucindo Ítalo E. P. da Silva Cynthia C. Silva Róbson R. Teixeira Sérgio O. de Paula Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus |
| description |
Mayaro virus (MAYV) is a neglected arthropod-borne virus found in the Americas. MAYV infection results in Mayaro fever, a non-lethal debilitating disease characterized by a strong inflammatory response affecting the joints and muscles. MAYV was once considered endemic to forested areas in Brazil but has managed to adapt and spread to urban regions using new vectors, such as <i>Aedes aegypti</i>, and has the potential to cause serious epidemics in the future. Currently, there are no vaccines or specific treatments against MAYV. In this study, the antiviral activity of a series of synthetic cyclic ketones were evaluated for the first time against MAYV. Twenty-four compounds were screened in a cell viability assay, and eight were selected for further evaluation. Effective concentration (EC<sub>50</sub>) and selectivity index (SI) were calculated and compound 9-(5-(4-chlorophenyl]furan-2-yl)-3,6-dimethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2))-dione (9) (EC<sub>50</sub> = 21.5 µmol·L<sup>−1</sup>, SI = 15.8) was selected for mechanism of action assays. The substance was able to reduce viral activity by approximately 70% in both pre-treatment and post-treatment assays. |
| format |
article |
| author |
Luciana S. Fernandes Milene L. da Silva Roberto S. Dias Marcel S. da S. Lucindo Ítalo E. P. da Silva Cynthia C. Silva Róbson R. Teixeira Sérgio O. de Paula |
| author_facet |
Luciana S. Fernandes Milene L. da Silva Roberto S. Dias Marcel S. da S. Lucindo Ítalo E. P. da Silva Cynthia C. Silva Róbson R. Teixeira Sérgio O. de Paula |
| author_sort |
Luciana S. Fernandes |
| title |
Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus |
| title_short |
Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus |
| title_full |
Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus |
| title_fullStr |
Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus |
| title_full_unstemmed |
Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus |
| title_sort |
evaluation of antiviral activity of cyclic ketones against mayaro virus |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/bcf1744c16904acfa9e9f16270792f76 |
| work_keys_str_mv |
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| _version_ |
1718410179647635456 |