Post-operative insulin resistance

Post-operative insulin resistance (IR) is a recognised marker of surgical stress. However, the reasons underlying post-operative IR and its clinical value are still unclear. IR has been described as a pathological condition, in which organs and tissues fail to respond to the hormone insulin, resulti...

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Autores principales:	Irina Aleksandrovna Tarasova, Alexey Leonidovich Shestakov, Vladimir Vladimirovich Nikoda
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	insulin resistance glucose metabolism surgical stress post-operative stress hyperglycaemia Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/bcf4543161f14799a513dbd42c1c9651
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spelling	oai:doaj.org-article:bcf4543161f14799a513dbd42c1c96512021-11-14T09:00:21ZPost-operative insulin resistance2072-03512072-037810.14341/7637https://doaj.org/article/bcf4543161f14799a513dbd42c1c96512017-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8171https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Post-operative insulin resistance (IR) is a recognised marker of surgical stress. However, the reasons underlying post-operative IR and its clinical value are still unclear. IR has been described as a pathological condition, in which organs and tissues fail to respond to the hormone insulin, resulting in acute hyperglycaemia. Post-operative IR in patients without type 2 diabetes has been identified as an independent, negative predictor of post-operative outcome. Studies have shown a direct relationship between post-operative morbidity (including complications from infection) and total mortality in patients with acute hyperglycaemia compared with diabetic patients. IR and stress-induced hyperglycaemia in the early post-operative period may be corrected by insulin infusion; however, this has often been associated with hypoglycaemia. Detection and modification of risk factors in the pre- and intra-operative periods may decrease the frequency of IR and hyperglycaemia and eliminate the use of insulin. In this literature review, the mechanisms underlying the development and prevention of post-operative IR, and its clinical value are discussed. This study demonstrates the relationship between IR and post-operative morbidity, highlighting the benefits of a complex approach to prevent the adverse events of post-operative IR and stress-induced hyperglycaemia.Irina Aleksandrovna TarasovaAlexey Leonidovich ShestakovVladimir Vladimirovich NikodaEndocrinology Research Centrearticleinsulin resistanceglucose metabolismsurgical stresspost-operative stresshyperglycaemiaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 2, Pp 119-125 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	insulin resistance glucose metabolism surgical stress post-operative stress hyperglycaemia Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	insulin resistance glucose metabolism surgical stress post-operative stress hyperglycaemia Nutritional diseases. Deficiency diseases RC620-627 Irina Aleksandrovna Tarasova Alexey Leonidovich Shestakov Vladimir Vladimirovich Nikoda Post-operative insulin resistance
description	Post-operative insulin resistance (IR) is a recognised marker of surgical stress. However, the reasons underlying post-operative IR and its clinical value are still unclear. IR has been described as a pathological condition, in which organs and tissues fail to respond to the hormone insulin, resulting in acute hyperglycaemia. Post-operative IR in patients without type 2 diabetes has been identified as an independent, negative predictor of post-operative outcome. Studies have shown a direct relationship between post-operative morbidity (including complications from infection) and total mortality in patients with acute hyperglycaemia compared with diabetic patients. IR and stress-induced hyperglycaemia in the early post-operative period may be corrected by insulin infusion; however, this has often been associated with hypoglycaemia. Detection and modification of risk factors in the pre- and intra-operative periods may decrease the frequency of IR and hyperglycaemia and eliminate the use of insulin. In this literature review, the mechanisms underlying the development and prevention of post-operative IR, and its clinical value are discussed. This study demonstrates the relationship between IR and post-operative morbidity, highlighting the benefits of a complex approach to prevent the adverse events of post-operative IR and stress-induced hyperglycaemia.
format	article
author	Irina Aleksandrovna Tarasova Alexey Leonidovich Shestakov Vladimir Vladimirovich Nikoda
author_facet	Irina Aleksandrovna Tarasova Alexey Leonidovich Shestakov Vladimir Vladimirovich Nikoda
author_sort	Irina Aleksandrovna Tarasova
title	Post-operative insulin resistance
title_short	Post-operative insulin resistance
title_full	Post-operative insulin resistance
title_fullStr	Post-operative insulin resistance
title_full_unstemmed	Post-operative insulin resistance
title_sort	post-operative insulin resistance
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/bcf4543161f14799a513dbd42c1c9651
work_keys_str_mv	AT irinaaleksandrovnatarasova postoperativeinsulinresistance AT alexeyleonidovichshestakov postoperativeinsulinresistance AT vladimirvladimirovichnikoda postoperativeinsulinresistance
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Post-operative insulin resistance

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