ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease

Patients with mitochondrial disease exhibit disrupted pyruvate oxidation, resulting in intraoperative and perioperative physiologic derangements. Increased enzymatic conversion of pyruvate via lactate dehydrogenase during periods of fasting or stress can lead to metabolic decompensation, with rapid...

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Autores principales:	Sonal Sharma, Clifford Deerman, Michael H. Andreae, Conrad Myler
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/bcf5eb3a72054b46b12d6f050a1975aa
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spelling	oai:doaj.org-article:bcf5eb3a72054b46b12d6f050a1975aa2021-11-15T01:19:55ZECMO for Metabolic Crisis in a Patient with Mitochondrial Disease2090-639010.1155/2021/9914311https://doaj.org/article/bcf5eb3a72054b46b12d6f050a1975aa2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9914311https://doaj.org/toc/2090-6390Patients with mitochondrial disease exhibit disrupted pyruvate oxidation, resulting in intraoperative and perioperative physiologic derangements. Increased enzymatic conversion of pyruvate via lactate dehydrogenase during periods of fasting or stress can lead to metabolic decompensation, with rapid development of fatal lactic acidosis. We describe the intraoperative management and postoperative critical care of a patient with mitochondrial disease who presented for repair of esophageal perforation following repair of a paraesophageal hernia. His surgery was complicated by the development of metabolic crisis and severe lactic acidosis which became resistant to conventional therapy before ultimately resolving with the initiation of venoarterial extracorporeal membrane oxygenation (VA-ECMO).Sonal SharmaClifford DeermanMichael H. AndreaeConrad MylerHindawi LimitedarticleAnesthesiologyRD78.3-87.3ENCase Reports in Anesthesiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anesthesiology RD78.3-87.3
spellingShingle	Anesthesiology RD78.3-87.3 Sonal Sharma Clifford Deerman Michael H. Andreae Conrad Myler ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease
description	Patients with mitochondrial disease exhibit disrupted pyruvate oxidation, resulting in intraoperative and perioperative physiologic derangements. Increased enzymatic conversion of pyruvate via lactate dehydrogenase during periods of fasting or stress can lead to metabolic decompensation, with rapid development of fatal lactic acidosis. We describe the intraoperative management and postoperative critical care of a patient with mitochondrial disease who presented for repair of esophageal perforation following repair of a paraesophageal hernia. His surgery was complicated by the development of metabolic crisis and severe lactic acidosis which became resistant to conventional therapy before ultimately resolving with the initiation of venoarterial extracorporeal membrane oxygenation (VA-ECMO).
format	article
author	Sonal Sharma Clifford Deerman Michael H. Andreae Conrad Myler
author_facet	Sonal Sharma Clifford Deerman Michael H. Andreae Conrad Myler
author_sort	Sonal Sharma
title	ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease
title_short	ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease
title_full	ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease
title_fullStr	ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease
title_full_unstemmed	ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease
title_sort	ecmo for metabolic crisis in a patient with mitochondrial disease
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/bcf5eb3a72054b46b12d6f050a1975aa
work_keys_str_mv	AT sonalsharma ecmoformetaboliccrisisinapatientwithmitochondrialdisease AT clifforddeerman ecmoformetaboliccrisisinapatientwithmitochondrialdisease AT michaelhandreae ecmoformetaboliccrisisinapatientwithmitochondrialdisease AT conradmyler ecmoformetaboliccrisisinapatientwithmitochondrialdisease
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ECMO for Metabolic Crisis in a Patient with Mitochondrial Disease

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