Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes.
Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight gain and normal aging may contribute to metabolic dysfunction. To directly test this hypothesis a novel mouse model of adult onset-isolated GH deficiency (AOiGHD) was generated...
Guardado en:
Autores principales: | Raul M Luque, Qing Lin, José Córdoba-Chacón, Papasani V Subbaiah, Thorsten Buch, Ari Waisman, Hugo Vankelecom, Rhonda D Kineman |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
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Materias: | |
Acceso en línea: | https://doaj.org/article/bcfcd215a97b4e18a03b091d542bc302 |
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