Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).

The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europea...

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Autores principales: Rebecca Hein, Melanie Maranian, John L Hopper, Miroslaw K Kapuscinski, Melissa C Southey, Daniel J Park, Marjanka K Schmidt, Annegien Broeks, Frans B L Hogervorst, H Bas Bueno-de-Mesquita, Kenneth R Muir, Artitaya Lophatananon, Suthee Rattanamongkongul, Puttisak Puttawibul, Peter A Fasching, Alexander Hein, Arif B Ekici, Matthias W Beckmann, Olivia Fletcher, Nichola Johnson, Isabel dos Santos Silva, Julian Peto, Elinor Sawyer, Ian Tomlinson, Michael Kerin, Nicola Miller, Frederick Marmee, Andreas Schneeweiss, Christof Sohn, Barbara Burwinkel, Pascal Guénel, Emilie Cordina-Duverger, Florence Menegaux, Thérèse Truong, Stig E Bojesen, Børge G Nordestgaard, Henrik Flyger, Roger L Milne, Jose Ignacio Arias Perez, M Pilar Zamora, Javier Benítez, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina A Clarke, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Nazneen Rahman, Sheila Seal, Clare Turnbull, Anthony Renwick, Alfons Meindl, Sarah Schott, Claus R Bartram, Rita K Schmutzler, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, GENICA Network, Shan Wang-Gohrke, Thilo Dörk, Peter Schürmann, Johann H Karstens, Peter Hillemanns, Heli Nevanlinna, Tuomas Heikkinen, Kristiina Aittomäki, Carl Blomqvist, Natalia V Bogdanova, Iosif V Zalutsky, Natalia N Antonenkova, Marina Bermisheva, Darya Prokovieva, Albina Farahtdinova, Elza Khusnutdinova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana Hartikainen, Xiaoqing Chen, Jonathan Beesley, Kconfab Investigators, AOCS Group, Diether Lambrechts, Hui Zhao, Patrick Neven, Hans Wildiers, Stefan Nickels, Dieter Flesch-Janys, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Fergus J Couch, Janet E Olson, Xianshu Wang, Zachary Fredericksen, Graham G Giles, Laura Baglietto, Catriona A McLean, Gianluca Severi, Kenneth Offit, Mark Robson, Mia M Gaudet, Joseph Vijai, Grethe Grenaker Alnæs, Vessela Kristensen, Anne-Lise Børresen-Dale, Esther M John, Alexander Miron, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Jonine D Figueroa, Montserrat García-Closas, Jolanta Lissowska, Mark E Sherman, Maartje Hooning, John W M Martens, Caroline Seynaeve, Margriet Collée, Per Hall, Keith Humpreys, Kamila Czene, Jianjun Liu, Angela Cox, Ian W Brock, Simon S Cross, Malcolm W R Reed, Shahana Ahmed, Maya Ghoussaini, Paul D P Pharoah, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Anna Jakubowska, Katarzyna Jaworska, Katarzyna Durda, Elżbieta Złowocka, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James McKay, Chen-Yang Shen, Jyh-Cherng Yu, Huan-Ming Hsu, Ming-Feng Hou, Nick Orr, Minouk Schoemaker, Alan Ashworth, Anthony Swerdlow, Amy Trentham-Dietz, Polly A Newcomb, Linda Titus, Kathleen M Egan, Georgia Chenevix-Trench, Antonis C Antoniou, Manjeet K Humphreys, Jonathan Morrison, Jenny Chang-Claude, Douglas F Easton, Alison M Dunning
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Publicado: Public Library of Science (PLoS) 2012
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record_format dspace
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rebecca Hein
Melanie Maranian
John L Hopper
Miroslaw K Kapuscinski
Melissa C Southey
Daniel J Park
Marjanka K Schmidt
Annegien Broeks
Frans B L Hogervorst
H Bas Bueno-de-Mesquita
Kenneth R Muir
Artitaya Lophatananon
Suthee Rattanamongkongul
Puttisak Puttawibul
Peter A Fasching
Alexander Hein
Arif B Ekici
Matthias W Beckmann
Olivia Fletcher
Nichola Johnson
Isabel dos Santos Silva
Julian Peto
Elinor Sawyer
Ian Tomlinson
Michael Kerin
Nicola Miller
Frederick Marmee
Andreas Schneeweiss
Christof Sohn
Barbara Burwinkel
Pascal Guénel
Emilie Cordina-Duverger
Florence Menegaux
Thérèse Truong
Stig E Bojesen
Børge G Nordestgaard
Henrik Flyger
Roger L Milne
Jose Ignacio Arias Perez
M Pilar Zamora
Javier Benítez
Hoda Anton-Culver
Argyrios Ziogas
Leslie Bernstein
Christina A Clarke
Hermann Brenner
Heiko Müller
Volker Arndt
Christa Stegmaier
Nazneen Rahman
Sheila Seal
Clare Turnbull
Anthony Renwick
Alfons Meindl
Sarah Schott
Claus R Bartram
Rita K Schmutzler
Hiltrud Brauch
Ute Hamann
Yon-Dschun Ko
GENICA Network
Shan Wang-Gohrke
Thilo Dörk
Peter Schürmann
Johann H Karstens
Peter Hillemanns
Heli Nevanlinna
Tuomas Heikkinen
Kristiina Aittomäki
Carl Blomqvist
Natalia V Bogdanova
Iosif V Zalutsky
Natalia N Antonenkova
Marina Bermisheva
Darya Prokovieva
Albina Farahtdinova
Elza Khusnutdinova
Annika Lindblom
Sara Margolin
Arto Mannermaa
Vesa Kataja
Veli-Matti Kosma
Jaana Hartikainen
Xiaoqing Chen
Jonathan Beesley
Kconfab Investigators
AOCS Group
Diether Lambrechts
Hui Zhao
Patrick Neven
Hans Wildiers
Stefan Nickels
Dieter Flesch-Janys
Paolo Radice
Paolo Peterlongo
Siranoush Manoukian
Monica Barile
Fergus J Couch
Janet E Olson
Xianshu Wang
Zachary Fredericksen
Graham G Giles
Laura Baglietto
Catriona A McLean
Gianluca Severi
Kenneth Offit
Mark Robson
Mia M Gaudet
Joseph Vijai
Grethe Grenaker Alnæs
Vessela Kristensen
Anne-Lise Børresen-Dale
Esther M John
Alexander Miron
Robert Winqvist
Katri Pylkäs
Arja Jukkola-Vuorinen
Mervi Grip
Irene L Andrulis
Julia A Knight
Gord Glendon
Anna Marie Mulligan
Jonine D Figueroa
Montserrat García-Closas
Jolanta Lissowska
Mark E Sherman
Maartje Hooning
John W M Martens
Caroline Seynaeve
Margriet Collée
Per Hall
Keith Humpreys
Kamila Czene
Jianjun Liu
Angela Cox
Ian W Brock
Simon S Cross
Malcolm W R Reed
Shahana Ahmed
Maya Ghoussaini
Paul D P Pharoah
Daehee Kang
Keun-Young Yoo
Dong-Young Noh
Anna Jakubowska
Katarzyna Jaworska
Katarzyna Durda
Elżbieta Złowocka
Suleeporn Sangrajrang
Valerie Gaborieau
Paul Brennan
James McKay
Chen-Yang Shen
Jyh-Cherng Yu
Huan-Ming Hsu
Ming-Feng Hou
Nick Orr
Minouk Schoemaker
Alan Ashworth
Anthony Swerdlow
Amy Trentham-Dietz
Polly A Newcomb
Linda Titus
Kathleen M Egan
Georgia Chenevix-Trench
Antonis C Antoniou
Manjeet K Humphreys
Jonathan Morrison
Jenny Chang-Claude
Douglas F Easton
Alison M Dunning
Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
description The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER-) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26-1.48), p = 7.6 × 10(-14) in Asians and 1.09 (95% CI 1.07-1.11), p = 6.8 × 10(-18) in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19-1.41), p = 1.2 × 10(-9) in Asians and 1.12 (95% CI 1.08-1.17), p = 3.8 × 10(-9) in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER- than ER+ tumours in Europeans [OR (ER-) = 1.20 (95% CI 1.15-1.25), p = 1.8 × 10(-17) versus OR (ER+) = 1.07 (95% CI 1.04-1.1), p = 1.3 × 10(-7), p(heterogeneity) = 5.1 × 10(-6)]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER- tumours.
format article
author Rebecca Hein
Melanie Maranian
John L Hopper
Miroslaw K Kapuscinski
Melissa C Southey
Daniel J Park
Marjanka K Schmidt
Annegien Broeks
Frans B L Hogervorst
H Bas Bueno-de-Mesquita
Kenneth R Muir
Artitaya Lophatananon
Suthee Rattanamongkongul
Puttisak Puttawibul
Peter A Fasching
Alexander Hein
Arif B Ekici
Matthias W Beckmann
Olivia Fletcher
Nichola Johnson
Isabel dos Santos Silva
Julian Peto
Elinor Sawyer
Ian Tomlinson
Michael Kerin
Nicola Miller
Frederick Marmee
Andreas Schneeweiss
Christof Sohn
Barbara Burwinkel
Pascal Guénel
Emilie Cordina-Duverger
Florence Menegaux
Thérèse Truong
Stig E Bojesen
Børge G Nordestgaard
Henrik Flyger
Roger L Milne
Jose Ignacio Arias Perez
M Pilar Zamora
Javier Benítez
Hoda Anton-Culver
Argyrios Ziogas
Leslie Bernstein
Christina A Clarke
Hermann Brenner
Heiko Müller
Volker Arndt
Christa Stegmaier
Nazneen Rahman
Sheila Seal
Clare Turnbull
Anthony Renwick
Alfons Meindl
Sarah Schott
Claus R Bartram
Rita K Schmutzler
Hiltrud Brauch
Ute Hamann
Yon-Dschun Ko
GENICA Network
Shan Wang-Gohrke
Thilo Dörk
Peter Schürmann
Johann H Karstens
Peter Hillemanns
Heli Nevanlinna
Tuomas Heikkinen
Kristiina Aittomäki
Carl Blomqvist
Natalia V Bogdanova
Iosif V Zalutsky
Natalia N Antonenkova
Marina Bermisheva
Darya Prokovieva
Albina Farahtdinova
Elza Khusnutdinova
Annika Lindblom
Sara Margolin
Arto Mannermaa
Vesa Kataja
Veli-Matti Kosma
Jaana Hartikainen
Xiaoqing Chen
Jonathan Beesley
Kconfab Investigators
AOCS Group
Diether Lambrechts
Hui Zhao
Patrick Neven
Hans Wildiers
Stefan Nickels
Dieter Flesch-Janys
Paolo Radice
Paolo Peterlongo
Siranoush Manoukian
Monica Barile
Fergus J Couch
Janet E Olson
Xianshu Wang
Zachary Fredericksen
Graham G Giles
Laura Baglietto
Catriona A McLean
Gianluca Severi
Kenneth Offit
Mark Robson
Mia M Gaudet
Joseph Vijai
Grethe Grenaker Alnæs
Vessela Kristensen
Anne-Lise Børresen-Dale
Esther M John
Alexander Miron
Robert Winqvist
Katri Pylkäs
Arja Jukkola-Vuorinen
Mervi Grip
Irene L Andrulis
Julia A Knight
Gord Glendon
Anna Marie Mulligan
Jonine D Figueroa
Montserrat García-Closas
Jolanta Lissowska
Mark E Sherman
Maartje Hooning
John W M Martens
Caroline Seynaeve
Margriet Collée
Per Hall
Keith Humpreys
Kamila Czene
Jianjun Liu
Angela Cox
Ian W Brock
Simon S Cross
Malcolm W R Reed
Shahana Ahmed
Maya Ghoussaini
Paul D P Pharoah
Daehee Kang
Keun-Young Yoo
Dong-Young Noh
Anna Jakubowska
Katarzyna Jaworska
Katarzyna Durda
Elżbieta Złowocka
Suleeporn Sangrajrang
Valerie Gaborieau
Paul Brennan
James McKay
Chen-Yang Shen
Jyh-Cherng Yu
Huan-Ming Hsu
Ming-Feng Hou
Nick Orr
Minouk Schoemaker
Alan Ashworth
Anthony Swerdlow
Amy Trentham-Dietz
Polly A Newcomb
Linda Titus
Kathleen M Egan
Georgia Chenevix-Trench
Antonis C Antoniou
Manjeet K Humphreys
Jonathan Morrison
Jenny Chang-Claude
Douglas F Easton
Alison M Dunning
author_facet Rebecca Hein
Melanie Maranian
John L Hopper
Miroslaw K Kapuscinski
Melissa C Southey
Daniel J Park
Marjanka K Schmidt
Annegien Broeks
Frans B L Hogervorst
H Bas Bueno-de-Mesquita
Kenneth R Muir
Artitaya Lophatananon
Suthee Rattanamongkongul
Puttisak Puttawibul
Peter A Fasching
Alexander Hein
Arif B Ekici
Matthias W Beckmann
Olivia Fletcher
Nichola Johnson
Isabel dos Santos Silva
Julian Peto
Elinor Sawyer
Ian Tomlinson
Michael Kerin
Nicola Miller
Frederick Marmee
Andreas Schneeweiss
Christof Sohn
Barbara Burwinkel
Pascal Guénel
Emilie Cordina-Duverger
Florence Menegaux
Thérèse Truong
Stig E Bojesen
Børge G Nordestgaard
Henrik Flyger
Roger L Milne
Jose Ignacio Arias Perez
M Pilar Zamora
Javier Benítez
Hoda Anton-Culver
Argyrios Ziogas
Leslie Bernstein
Christina A Clarke
Hermann Brenner
Heiko Müller
Volker Arndt
Christa Stegmaier
Nazneen Rahman
Sheila Seal
Clare Turnbull
Anthony Renwick
Alfons Meindl
Sarah Schott
Claus R Bartram
Rita K Schmutzler
Hiltrud Brauch
Ute Hamann
Yon-Dschun Ko
GENICA Network
Shan Wang-Gohrke
Thilo Dörk
Peter Schürmann
Johann H Karstens
Peter Hillemanns
Heli Nevanlinna
Tuomas Heikkinen
Kristiina Aittomäki
Carl Blomqvist
Natalia V Bogdanova
Iosif V Zalutsky
Natalia N Antonenkova
Marina Bermisheva
Darya Prokovieva
Albina Farahtdinova
Elza Khusnutdinova
Annika Lindblom
Sara Margolin
Arto Mannermaa
Vesa Kataja
Veli-Matti Kosma
Jaana Hartikainen
Xiaoqing Chen
Jonathan Beesley
Kconfab Investigators
AOCS Group
Diether Lambrechts
Hui Zhao
Patrick Neven
Hans Wildiers
Stefan Nickels
Dieter Flesch-Janys
Paolo Radice
Paolo Peterlongo
Siranoush Manoukian
Monica Barile
Fergus J Couch
Janet E Olson
Xianshu Wang
Zachary Fredericksen
Graham G Giles
Laura Baglietto
Catriona A McLean
Gianluca Severi
Kenneth Offit
Mark Robson
Mia M Gaudet
Joseph Vijai
Grethe Grenaker Alnæs
Vessela Kristensen
Anne-Lise Børresen-Dale
Esther M John
Alexander Miron
Robert Winqvist
Katri Pylkäs
Arja Jukkola-Vuorinen
Mervi Grip
Irene L Andrulis
Julia A Knight
Gord Glendon
Anna Marie Mulligan
Jonine D Figueroa
Montserrat García-Closas
Jolanta Lissowska
Mark E Sherman
Maartje Hooning
John W M Martens
Caroline Seynaeve
Margriet Collée
Per Hall
Keith Humpreys
Kamila Czene
Jianjun Liu
Angela Cox
Ian W Brock
Simon S Cross
Malcolm W R Reed
Shahana Ahmed
Maya Ghoussaini
Paul D P Pharoah
Daehee Kang
Keun-Young Yoo
Dong-Young Noh
Anna Jakubowska
Katarzyna Jaworska
Katarzyna Durda
Elżbieta Złowocka
Suleeporn Sangrajrang
Valerie Gaborieau
Paul Brennan
James McKay
Chen-Yang Shen
Jyh-Cherng Yu
Huan-Ming Hsu
Ming-Feng Hou
Nick Orr
Minouk Schoemaker
Alan Ashworth
Anthony Swerdlow
Amy Trentham-Dietz
Polly A Newcomb
Linda Titus
Kathleen M Egan
Georgia Chenevix-Trench
Antonis C Antoniou
Manjeet K Humphreys
Jonathan Morrison
Jenny Chang-Claude
Douglas F Easton
Alison M Dunning
author_sort Rebecca Hein
title Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
title_short Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
title_full Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
title_fullStr Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
title_full_unstemmed Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).
title_sort comparison of 6q25 breast cancer hits from asian and european genome wide association studies in the breast cancer association consortium (bcac).
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/bcfd88daf90c42a397f31d12f9e2759f
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AT aocsgroup comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT janeteolson comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT annelisebørresendale comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT esthermjohn comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT alexandermiron comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT robertwinqvist comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT katripylkas comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT mervigrip comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT juliaaknight comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT maartjehooning comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT carolineseynaeve comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT margrietcollee comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT perhall comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT ianwbrock comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT simonscross comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT malcolmwrreed comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT shahanaahmed comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT mayaghoussaini comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT daeheekang comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT annajakubowska comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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AT suleepornsangrajrang comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT valeriegaborieau comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT paulbrennan comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT jamesmckay comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT chenyangshen comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT jyhcherngyu comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT huanminghsu comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT mingfenghou comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT nickorr comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT minoukschoemaker comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT alanashworth comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT anthonyswerdlow comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT amytrenthamdietz comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT pollyanewcomb comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT lindatitus comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT kathleenmegan comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT georgiachenevixtrench comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT antoniscantoniou comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT manjeetkhumphreys comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT jonathanmorrison comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT jennychangclaude comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT douglasfeaston comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
AT alisonmdunning comparisonof6q25breastcancerhitsfromasianandeuropeangenomewideassociationstudiesinthebreastcancerassociationconsortiumbcac
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spelling oai:doaj.org-article:bcfd88daf90c42a397f31d12f9e2759f2021-11-18T07:09:30ZComparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).1932-620310.1371/journal.pone.0042380https://doaj.org/article/bcfd88daf90c42a397f31d12f9e2759f2012-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0042380https://doaj.org/toc/1932-6203The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER-) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26-1.48), p = 7.6 × 10(-14) in Asians and 1.09 (95% CI 1.07-1.11), p = 6.8 × 10(-18) in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19-1.41), p = 1.2 × 10(-9) in Asians and 1.12 (95% CI 1.08-1.17), p = 3.8 × 10(-9) in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER- than ER+ tumours in Europeans [OR (ER-) = 1.20 (95% CI 1.15-1.25), p = 1.8 × 10(-17) versus OR (ER+) = 1.07 (95% CI 1.04-1.1), p = 1.3 × 10(-7), p(heterogeneity) = 5.1 × 10(-6)]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER- tumours.Rebecca HeinMelanie MaranianJohn L HopperMiroslaw K KapuscinskiMelissa C SoutheyDaniel J ParkMarjanka K SchmidtAnnegien BroeksFrans B L HogervorstH Bas Bueno-de-MesquitaKenneth R MuirArtitaya LophatananonSuthee RattanamongkongulPuttisak PuttawibulPeter A FaschingAlexander HeinArif B EkiciMatthias W BeckmannOlivia FletcherNichola JohnsonIsabel dos Santos SilvaJulian PetoElinor SawyerIan TomlinsonMichael KerinNicola MillerFrederick MarmeeAndreas SchneeweissChristof SohnBarbara BurwinkelPascal GuénelEmilie Cordina-DuvergerFlorence MenegauxThérèse TruongStig E BojesenBørge G NordestgaardHenrik FlygerRoger L MilneJose Ignacio Arias PerezM Pilar ZamoraJavier BenítezHoda Anton-CulverArgyrios ZiogasLeslie BernsteinChristina A ClarkeHermann BrennerHeiko MüllerVolker ArndtChrista StegmaierNazneen RahmanSheila SealClare TurnbullAnthony RenwickAlfons MeindlSarah SchottClaus R BartramRita K SchmutzlerHiltrud BrauchUte HamannYon-Dschun KoGENICA NetworkShan Wang-GohrkeThilo DörkPeter SchürmannJohann H KarstensPeter HillemannsHeli NevanlinnaTuomas HeikkinenKristiina AittomäkiCarl BlomqvistNatalia V BogdanovaIosif V ZalutskyNatalia N AntonenkovaMarina BermishevaDarya ProkovievaAlbina FarahtdinovaElza KhusnutdinovaAnnika LindblomSara MargolinArto MannermaaVesa KatajaVeli-Matti KosmaJaana HartikainenXiaoqing ChenJonathan BeesleyKconfab InvestigatorsAOCS GroupDiether LambrechtsHui ZhaoPatrick NevenHans WildiersStefan NickelsDieter Flesch-JanysPaolo RadicePaolo PeterlongoSiranoush ManoukianMonica BarileFergus J CouchJanet E OlsonXianshu WangZachary FredericksenGraham G GilesLaura BagliettoCatriona A McLeanGianluca SeveriKenneth OffitMark RobsonMia M GaudetJoseph VijaiGrethe Grenaker AlnæsVessela KristensenAnne-Lise Børresen-DaleEsther M JohnAlexander MironRobert WinqvistKatri PylkäsArja Jukkola-VuorinenMervi GripIrene L AndrulisJulia A KnightGord GlendonAnna Marie MulliganJonine D FigueroaMontserrat García-ClosasJolanta LissowskaMark E ShermanMaartje HooningJohn W M MartensCaroline SeynaeveMargriet ColléePer HallKeith HumpreysKamila CzeneJianjun LiuAngela CoxIan W BrockSimon S CrossMalcolm W R ReedShahana AhmedMaya GhoussainiPaul D P PharoahDaehee KangKeun-Young YooDong-Young NohAnna JakubowskaKatarzyna JaworskaKatarzyna DurdaElżbieta ZłowockaSuleeporn SangrajrangValerie GaborieauPaul BrennanJames McKayChen-Yang ShenJyh-Cherng YuHuan-Ming HsuMing-Feng HouNick OrrMinouk SchoemakerAlan AshworthAnthony SwerdlowAmy Trentham-DietzPolly A NewcombLinda TitusKathleen M EganGeorgia Chenevix-TrenchAntonis C AntoniouManjeet K HumphreysJonathan MorrisonJenny Chang-ClaudeDouglas F EastonAlison M DunningPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42380 (2012)