Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits

Eva Pipan,1 Alexandros Apostolou,2 Maria Bograkou,2 Petra Brooks,2 Patrick Vigren,2 Helena Gauffin2 1University Medical Centre Ljubljana, Ljubljana, Slovenia; 2Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenCorre...

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Autores principales:	Pipan E, Apostolou A, Bograkou M, Brooks P, Vigren P, Gauffin H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	epilepsy vagus nerve stimulation cognitive deficit cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bcffd93e748948539e8962e024828e82
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spelling	oai:doaj.org-article:bcffd93e748948539e8962e024828e822021-12-02T08:19:07ZVagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits1178-2021https://doaj.org/article/bcffd93e748948539e8962e024828e822020-05-01T00:00:00Zhttps://www.dovepress.com/vagal-nerve-stimulation-in-epilepsy-experiences-of-participants-with-c-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Eva Pipan,1 Alexandros Apostolou,2 Maria Bograkou,2 Petra Brooks,2 Patrick Vigren,2 Helena Gauffin2 1University Medical Centre Ljubljana, Ljubljana, Slovenia; 2Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenCorrespondence: Eva PipanUniversity Medical Centre Ljubljana, University of Ljubljana, Ljubljana, SloveniaEmail eva.pipan@yahoo.comIntroduction: The purpose of this study was to examine patients’ experiences of vagal nerve stimulation (VNS) with a special interest in patients with cognitive deficit (CD).Materials and Methods: An open, retrospective study was conducted on 82 patients with pharmacoresistant epilepsy, who were treated with VNS for at least 10 months. Based on the inability to live independently, they were divided into two groups: patients with cognitive deficit (CD group) and patients without cognitive deficit (non-CD group). A specially designed questionnaire was used for semi-structured interviews about patients’ experiences of VNS treatment.Results: Approximately one-third described a continuous reduction of seizure frequency of 50% or more and were regarded as responders. Fewer subjects in the CD group were responders than in the non-CD group. Approximately one-third of all subjects had no positive effect of VNS treatment. More CD patients described additional improvements and the most common were milder seizures and improved alertness. The most commonly reported adverse effect was hoarseness.Discussion: VNS treatment in patients without CD had better effect on seizure frequency reduction than in patients with CD, but many patients with CD reported other benefits from the treatment.Conclusion: Non-CD patients had higher seizure frequency reduction than CD patients during VNS treatment, but many CD patients described other benefits.Keywords: epilepsy, vagus nerve stimulation, cognitive deficit, cognitive dysfunction  Pipan EApostolou ABograkou MBrooks PVigren PGauffin HDove Medical Pressarticleepilepsyvagus nerve stimulationcognitive deficitcognitive dysfunctionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1181-1188 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	epilepsy vagus nerve stimulation cognitive deficit cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	epilepsy vagus nerve stimulation cognitive deficit cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pipan E Apostolou A Bograkou M Brooks P Vigren P Gauffin H Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits
description	Eva Pipan,1 Alexandros Apostolou,2 Maria Bograkou,2 Petra Brooks,2 Patrick Vigren,2 Helena Gauffin2 1University Medical Centre Ljubljana, Ljubljana, Slovenia; 2Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SwedenCorrespondence: Eva PipanUniversity Medical Centre Ljubljana, University of Ljubljana, Ljubljana, SloveniaEmail eva.pipan@yahoo.comIntroduction: The purpose of this study was to examine patients’ experiences of vagal nerve stimulation (VNS) with a special interest in patients with cognitive deficit (CD).Materials and Methods: An open, retrospective study was conducted on 82 patients with pharmacoresistant epilepsy, who were treated with VNS for at least 10 months. Based on the inability to live independently, they were divided into two groups: patients with cognitive deficit (CD group) and patients without cognitive deficit (non-CD group). A specially designed questionnaire was used for semi-structured interviews about patients’ experiences of VNS treatment.Results: Approximately one-third described a continuous reduction of seizure frequency of 50% or more and were regarded as responders. Fewer subjects in the CD group were responders than in the non-CD group. Approximately one-third of all subjects had no positive effect of VNS treatment. More CD patients described additional improvements and the most common were milder seizures and improved alertness. The most commonly reported adverse effect was hoarseness.Discussion: VNS treatment in patients without CD had better effect on seizure frequency reduction than in patients with CD, but many patients with CD reported other benefits from the treatment.Conclusion: Non-CD patients had higher seizure frequency reduction than CD patients during VNS treatment, but many CD patients described other benefits.Keywords: epilepsy, vagus nerve stimulation, cognitive deficit, cognitive dysfunction
format	article
author	Pipan E Apostolou A Bograkou M Brooks P Vigren P Gauffin H
author_facet	Pipan E Apostolou A Bograkou M Brooks P Vigren P Gauffin H
author_sort	Pipan E
title	Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits
title_short	Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits
title_full	Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits
title_fullStr	Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits
title_full_unstemmed	Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits
title_sort	vagal nerve stimulation in epilepsy: experiences of participants with cognitive deficits
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bcffd93e748948539e8962e024828e82
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Vagal Nerve Stimulation in Epilepsy: Experiences of Participants with Cognitive Deficits

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