Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity.

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Autores principales: Anja Waizenegger, Madhusoodanan Urulangodi, Carl P. Lehmann, Teresa Anne Clarisse Reyes, Irene Saugar, José Antonio Tercero, Barnabas Szakal, Dana Branzei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/bd031adcb9114b46a9b98466291010e6
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spelling oai:doaj.org-article:bd031adcb9114b46a9b98466291010e62021-12-02T17:32:41ZMus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity10.1038/s41467-020-19503-42041-1723https://doaj.org/article/bd031adcb9114b46a9b98466291010e62020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19503-4https://doaj.org/toc/2041-1723Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity.Anja WaizeneggerMadhusoodanan UrulangodiCarl P. LehmannTeresa Anne Clarisse ReyesIrene SaugarJosé Antonio TerceroBarnabas SzakalDana BranzeiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anja Waizenegger
Madhusoodanan Urulangodi
Carl P. Lehmann
Teresa Anne Clarisse Reyes
Irene Saugar
José Antonio Tercero
Barnabas Szakal
Dana Branzei
Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
description Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity.
format article
author Anja Waizenegger
Madhusoodanan Urulangodi
Carl P. Lehmann
Teresa Anne Clarisse Reyes
Irene Saugar
José Antonio Tercero
Barnabas Szakal
Dana Branzei
author_facet Anja Waizenegger
Madhusoodanan Urulangodi
Carl P. Lehmann
Teresa Anne Clarisse Reyes
Irene Saugar
José Antonio Tercero
Barnabas Szakal
Dana Branzei
author_sort Anja Waizenegger
title Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
title_short Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
title_full Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
title_fullStr Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
title_full_unstemmed Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
title_sort mus81-mms4 endonuclease is an esc2-stubl-cullin8 mitotic substrate impacting on genome integrity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/bd031adcb9114b46a9b98466291010e6
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