Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
The aim of this study was to isolate a filamentous nitrogen-fixing cyanobacterium Nostoc sphaeroides (NS) from brackish water of Chilika Lake, Odisha coast, and exploration of its use in the biosynthesis of silver-nanoparticles (AgNPs) against the urinary tract–infecting bacterial strains. The synth...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Taylor & Francis Group
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/bd07146dc95a407e89ea02be2e19c459 |
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| Sumario: | The aim of this study was to isolate a filamentous nitrogen-fixing cyanobacterium Nostoc sphaeroides (NS) from brackish water of Chilika Lake, Odisha coast, and exploration of its use in the biosynthesis of silver-nanoparticles (AgNPs) against the urinary tract–infecting bacterial strains. The synthesized NS-AgNPs were structurally characterized by analytical techniques such as UV-visible-spectrophotometry, FTIR, XRD, SEM and SEM-EDX. The antibacterial efficacy of synthesized AgNPs had remarkable in vitro activities with the MIC value of 50 mg/ml. Moreover, Nostocine A, the inherent bioactive compound of Nostoc sp. was further investigated for molecular docking studies against the targeted bacterial DNA gyrase (Escherichia coli) and the obtained docking score was −7.9 kCal/mol as compared with the standard drug, Ciprofloxacin of a docking score −7.8 kCal/mol. The concordance between molecular docking and experimental results is excellent. Thus, the biogenic-synthesized “N. sphaeroides-AgNPs” would be used as an antibacterial agent in future. |
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