Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria

The aim of this study was to isolate a filamentous nitrogen-fixing cyanobacterium Nostoc sphaeroides (NS) from brackish water of Chilika Lake, Odisha coast, and exploration of its use in the biosynthesis of silver-nanoparticles (AgNPs) against the urinary tract–infecting bacterial strains. The synth...

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Autores principales:	Chita Ranjan Sahoo, Surendra Swain, Alexander Maniangat Luke, Sudhir Kumar Paidesetty, Rabindra Nath Padhy
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	nostoc sphaeroides silver-nanoparticles molecular docking urinary tract infection Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/bd07146dc95a407e89ea02be2e19c459
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spelling	oai:doaj.org-article:bd07146dc95a407e89ea02be2e19c4592021-11-26T11:19:47ZBiogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria1658-365510.1080/16583655.2021.2005909https://doaj.org/article/bd07146dc95a407e89ea02be2e19c4592021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/16583655.2021.2005909https://doaj.org/toc/1658-3655The aim of this study was to isolate a filamentous nitrogen-fixing cyanobacterium Nostoc sphaeroides (NS) from brackish water of Chilika Lake, Odisha coast, and exploration of its use in the biosynthesis of silver-nanoparticles (AgNPs) against the urinary tract–infecting bacterial strains. The synthesized NS-AgNPs were structurally characterized by analytical techniques such as UV-visible-spectrophotometry, FTIR, XRD, SEM and SEM-EDX. The antibacterial efficacy of synthesized AgNPs had remarkable in vitro activities with the MIC value of 50 mg/ml. Moreover, Nostocine A, the inherent bioactive compound of Nostoc sp. was further investigated for molecular docking studies against the targeted bacterial DNA gyrase (Escherichia coli) and the obtained docking score was −7.9 kCal/mol as compared with the standard drug, Ciprofloxacin of a docking score −7.8 kCal/mol. The concordance between molecular docking and experimental results is excellent. Thus, the biogenic-synthesized “N. sphaeroides-AgNPs” would be used as an antibacterial agent in future.Chita Ranjan SahooSurendra SwainAlexander Maniangat LukeSudhir Kumar PaidesettyRabindra Nath PadhyTaylor & Francis Grouparticlenostoc sphaeroidessilver-nanoparticlesmolecular dockingurinary tract infectionScience (General)Q1-390ENJournal of Taibah University for Science, Vol 15, Iss 1, Pp 805-813 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nostoc sphaeroides silver-nanoparticles molecular docking urinary tract infection Science (General) Q1-390
spellingShingle	nostoc sphaeroides silver-nanoparticles molecular docking urinary tract infection Science (General) Q1-390 Chita Ranjan Sahoo Surendra Swain Alexander Maniangat Luke Sudhir Kumar Paidesetty Rabindra Nath Padhy Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
description	The aim of this study was to isolate a filamentous nitrogen-fixing cyanobacterium Nostoc sphaeroides (NS) from brackish water of Chilika Lake, Odisha coast, and exploration of its use in the biosynthesis of silver-nanoparticles (AgNPs) against the urinary tract–infecting bacterial strains. The synthesized NS-AgNPs were structurally characterized by analytical techniques such as UV-visible-spectrophotometry, FTIR, XRD, SEM and SEM-EDX. The antibacterial efficacy of synthesized AgNPs had remarkable in vitro activities with the MIC value of 50 mg/ml. Moreover, Nostocine A, the inherent bioactive compound of Nostoc sp. was further investigated for molecular docking studies against the targeted bacterial DNA gyrase (Escherichia coli) and the obtained docking score was −7.9 kCal/mol as compared with the standard drug, Ciprofloxacin of a docking score −7.8 kCal/mol. The concordance between molecular docking and experimental results is excellent. Thus, the biogenic-synthesized “N. sphaeroides-AgNPs” would be used as an antibacterial agent in future.
format	article
author	Chita Ranjan Sahoo Surendra Swain Alexander Maniangat Luke Sudhir Kumar Paidesetty Rabindra Nath Padhy
author_facet	Chita Ranjan Sahoo Surendra Swain Alexander Maniangat Luke Sudhir Kumar Paidesetty Rabindra Nath Padhy
author_sort	Chita Ranjan Sahoo
title	Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
title_short	Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
title_full	Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
title_fullStr	Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
title_full_unstemmed	Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
title_sort	biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/bd07146dc95a407e89ea02be2e19c459
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Biogenic synthesis of silver-nanoparticles with the brackish water cyanobacterium Nostoc sphaeroides and assessment of antibacterial activity against urinary tract infecting bacteria

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