QT and P-wave dispersion during the manic phase of bipolar disorder

Mehmet Gurkan Gurok,1 Hasan Korkmaz,2 Sevler Yıldız,1 Dilek Bakış,1 Murad Atmaca11Fırat University, School of Medicine, Department of Psychiatry, Elazig, Turkey; 2Fırat University, School of Medicine, Department of Cardiology, Elazig, TurkeyBackground and aim: Patients with bipolar disorder (BD) are...

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Autores principales:	Gurok MG, Korkmaz H, Yıldız S, Bakış D, Atmaca M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Mania Bipolar disorder QT dispersion P-wave dispersion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bd075ccd33714021a5af0762cb77b5bb
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spelling	oai:doaj.org-article:bd075ccd33714021a5af0762cb77b5bb2021-12-02T04:09:21ZQT and P-wave dispersion during the manic phase of bipolar disorder1178-2021https://doaj.org/article/bd075ccd33714021a5af0762cb77b5bb2019-07-01T00:00:00Zhttps://www.dovepress.com/qt-and-p-wave-dispersion-during-the-manic-phase-of-bipolar-disorder-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mehmet Gurkan Gurok,1 Hasan Korkmaz,2 Sevler Yıldız,1 Dilek Bakış,1 Murad Atmaca11Fırat University, School of Medicine, Department of Psychiatry, Elazig, Turkey; 2Fırat University, School of Medicine, Department of Cardiology, Elazig, TurkeyBackground and aim: Patients with bipolar disorder (BD) are at increased risk for cardiovascular diseases and complications. This increased risk is considered to be associated with the autonomic nervous system (ANS) abnormalities. However, there is little or no documentation of the relationship between this increased risk and the phases of BD. In this study, we aimed to compare the changes in the QT dispersion (QTd) and P-wave dispersion (Pd), which are predictors of sudden cardiac death and atrial fibrillation, between the patients with manic BD and healthy controls.Participants and methods: The study included a patient group of 44 patients (26 female and 18 male) that were hospitalized due to a diagnosis of manic BD and met the inclusion criteria, and a control group of 34 age- and gender-matched healthy individuals (21 female and 13 male) with no history of psychiatric and neurological disorders. The QTd and Pd values were determined in each participant by performing the standard 12-lead body surface electrocardiography (ECG).Results: The principal electrocardiographic indicators including corrected maximum QT interval, corrected QT dispersion, and minimum P-wave duration significantly increased in the patient group compared to the control group (t=2.815, p<0.01; t=4.935, p<0.001; t=3.337, p<0.001, respectively).Conclusion: The results indicated that patients with manic BD are at increased risk for cardiovascular autonomic dysfunction. Therefore, clinicians should be more careful about ECG changes and related possible cardiac conduction problems such as cardiac arrthythmias in patients with manic BD. Further longitudinal studies are needed to investigate BD and its phases (depression, mania, and hypomania) with regard to ANS and cardiac abnormalities.Keywords: mania, bipolar disorder, QT dispersion, P-wave dispersionGurok MGKorkmaz HYıldız SBakış DAtmaca MDove Medical PressarticleManiaBipolar disorderQT dispersionP-wave dispersionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1805-1811 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mania Bipolar disorder QT dispersion P-wave dispersion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Mania Bipolar disorder QT dispersion P-wave dispersion Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gurok MG Korkmaz H Yıldız S Bakış D Atmaca M QT and P-wave dispersion during the manic phase of bipolar disorder
description	Mehmet Gurkan Gurok,1 Hasan Korkmaz,2 Sevler Yıldız,1 Dilek Bakış,1 Murad Atmaca11Fırat University, School of Medicine, Department of Psychiatry, Elazig, Turkey; 2Fırat University, School of Medicine, Department of Cardiology, Elazig, TurkeyBackground and aim: Patients with bipolar disorder (BD) are at increased risk for cardiovascular diseases and complications. This increased risk is considered to be associated with the autonomic nervous system (ANS) abnormalities. However, there is little or no documentation of the relationship between this increased risk and the phases of BD. In this study, we aimed to compare the changes in the QT dispersion (QTd) and P-wave dispersion (Pd), which are predictors of sudden cardiac death and atrial fibrillation, between the patients with manic BD and healthy controls.Participants and methods: The study included a patient group of 44 patients (26 female and 18 male) that were hospitalized due to a diagnosis of manic BD and met the inclusion criteria, and a control group of 34 age- and gender-matched healthy individuals (21 female and 13 male) with no history of psychiatric and neurological disorders. The QTd and Pd values were determined in each participant by performing the standard 12-lead body surface electrocardiography (ECG).Results: The principal electrocardiographic indicators including corrected maximum QT interval, corrected QT dispersion, and minimum P-wave duration significantly increased in the patient group compared to the control group (t=2.815, p<0.01; t=4.935, p<0.001; t=3.337, p<0.001, respectively).Conclusion: The results indicated that patients with manic BD are at increased risk for cardiovascular autonomic dysfunction. Therefore, clinicians should be more careful about ECG changes and related possible cardiac conduction problems such as cardiac arrthythmias in patients with manic BD. Further longitudinal studies are needed to investigate BD and its phases (depression, mania, and hypomania) with regard to ANS and cardiac abnormalities.Keywords: mania, bipolar disorder, QT dispersion, P-wave dispersion
format	article
author	Gurok MG Korkmaz H Yıldız S Bakış D Atmaca M
author_facet	Gurok MG Korkmaz H Yıldız S Bakış D Atmaca M
author_sort	Gurok MG
title	QT and P-wave dispersion during the manic phase of bipolar disorder
title_short	QT and P-wave dispersion during the manic phase of bipolar disorder
title_full	QT and P-wave dispersion during the manic phase of bipolar disorder
title_fullStr	QT and P-wave dispersion during the manic phase of bipolar disorder
title_full_unstemmed	QT and P-wave dispersion during the manic phase of bipolar disorder
title_sort	qt and p-wave dispersion during the manic phase of bipolar disorder
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/bd075ccd33714021a5af0762cb77b5bb
work_keys_str_mv	AT gurokmg qtandpwavedispersionduringthemanicphaseofbipolardisorder AT korkmazh qtandpwavedispersionduringthemanicphaseofbipolardisorder AT yıldızs qtandpwavedispersionduringthemanicphaseofbipolardisorder AT bakısd qtandpwavedispersionduringthemanicphaseofbipolardisorder AT atmacam qtandpwavedispersionduringthemanicphaseofbipolardisorder
_version_	1718401456350953472

QT and P-wave dispersion during the manic phase of bipolar disorder

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