Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis

Objective To examine the effectiveness and safety of thermal ablative methods and myomectomy for the treatment of uterine fibroids. Materials and methods We searched EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, Scopus, CINAHL, ClinicalTrials.gov and Web of Science databases th...

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Autores principales:	Deku Liang, Juan Li, DanDan Liu, Hu Zhao, Yonghong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	focused ultrasound radiofrequency ablation myomectomy uterine fibroids meta-analysis Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/bd0ff4c0634b40c88f827fc654226f25
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spelling	oai:doaj.org-article:bd0ff4c0634b40c88f827fc654226f252021-11-04T15:00:41ZComparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis0265-67361464-515710.1080/02656736.2021.1996644https://doaj.org/article/bd0ff4c0634b40c88f827fc654226f252021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.1996644https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Objective To examine the effectiveness and safety of thermal ablative methods and myomectomy for the treatment of uterine fibroids. Materials and methods We searched EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, Scopus, CINAHL, ClinicalTrials.gov and Web of Science databases through April 2021. Clinical trials comparing the thermal ablative methods and myomectomy for the treatment of uterine fibroids were included. Results Thirteen studies including 4205 patients were eligible. The thermal ablative treatment group was associated with less major adverse events (only ultrasound guided high-intensity focused ultrasound) (RR, 0.111 [95% CI, 0.070–0.175], p=.0), shorter duration of hospital stays in observational studies (–0.1497 day, [95% CI, −1.593 to −0.321], p=.0) and in randomized controlled trials (RCTs) (–0.844 day, [95% CI, −0.1.142 to −0.546], p=.0), higher uterine fibroid symptom (UFS) score after operation (0.252 [95% CI, 0.165–0.339]; p=.0), transformed symptom severity (tSS) score after operation (0.515 [95% CI, 0.355–0.674]; p=.0) and quality of life (QoL) score after operation (0.188 [95% CI, 0.093–0.283]; p=.0) in comparison with myomectomy group. No statistically significant difference was found between the thermal ablative treatment group and myomectomy group with respect to reintervention rate and pregnancy rate. Conclusion The current data available demonstrate that thermal ablative methods were not inferior to myomectomy in the treatment of uterine fibroids. The findings in this study need to be further confirmed by large RCTs.Deku LiangJuan LiDanDan LiuHu ZhaoYonghong LinTaylor & Francis Grouparticlefocused ultrasoundradiofrequency ablationmyomectomyuterine fibroidsmeta-analysisMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 1571-1583 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	focused ultrasound radiofrequency ablation myomectomy uterine fibroids meta-analysis Medical technology R855-855.5
spellingShingle	focused ultrasound radiofrequency ablation myomectomy uterine fibroids meta-analysis Medical technology R855-855.5 Deku Liang Juan Li DanDan Liu Hu Zhao Yonghong Lin Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
description	Objective To examine the effectiveness and safety of thermal ablative methods and myomectomy for the treatment of uterine fibroids. Materials and methods We searched EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, Scopus, CINAHL, ClinicalTrials.gov and Web of Science databases through April 2021. Clinical trials comparing the thermal ablative methods and myomectomy for the treatment of uterine fibroids were included. Results Thirteen studies including 4205 patients were eligible. The thermal ablative treatment group was associated with less major adverse events (only ultrasound guided high-intensity focused ultrasound) (RR, 0.111 [95% CI, 0.070–0.175], p=.0), shorter duration of hospital stays in observational studies (–0.1497 day, [95% CI, −1.593 to −0.321], p=.0) and in randomized controlled trials (RCTs) (–0.844 day, [95% CI, −0.1.142 to −0.546], p=.0), higher uterine fibroid symptom (UFS) score after operation (0.252 [95% CI, 0.165–0.339]; p=.0), transformed symptom severity (tSS) score after operation (0.515 [95% CI, 0.355–0.674]; p=.0) and quality of life (QoL) score after operation (0.188 [95% CI, 0.093–0.283]; p=.0) in comparison with myomectomy group. No statistically significant difference was found between the thermal ablative treatment group and myomectomy group with respect to reintervention rate and pregnancy rate. Conclusion The current data available demonstrate that thermal ablative methods were not inferior to myomectomy in the treatment of uterine fibroids. The findings in this study need to be further confirmed by large RCTs.
format	article
author	Deku Liang Juan Li DanDan Liu Hu Zhao Yonghong Lin
author_facet	Deku Liang Juan Li DanDan Liu Hu Zhao Yonghong Lin
author_sort	Deku Liang
title	Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
title_short	Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
title_full	Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
title_fullStr	Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
title_full_unstemmed	Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
title_sort	comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/bd0ff4c0634b40c88f827fc654226f25
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Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis

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