A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles

Herein, chitosan nanoparticles (CS-NPs) were prepared and functionalized chemically with titanium dioxide nanoparticles (TiO2-NPs) to allow on-demand degradation of CS-NPs, using ultraviolet (UV) irradiation as a trigger. This is expected to allow drug release depending on patients' needs or ph...

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Autores principales:	Nusaiba Al-Nemrawi, Sukaina Nimrawi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	chitosan nanoparticles rhodamine titanium dioxide nanoparticles ultraviolet irradiation Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/bd10afb818c045968e334a0ad5077b37
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spelling	oai:doaj.org-article:bd10afb818c045968e334a0ad5077b372021-11-12T10:17:53ZA novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles2231-40400976-209410.4103/japtr.japtr_22_21https://doaj.org/article/bd10afb818c045968e334a0ad5077b372021-01-01T00:00:00Zhttp://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=4;spage=402;epage=407;aulast=Al-Nemrawihttps://doaj.org/toc/2231-4040https://doaj.org/toc/0976-2094Herein, chitosan nanoparticles (CS-NPs) were prepared and functionalized chemically with titanium dioxide nanoparticles (TiO2-NPs) to allow on-demand degradation of CS-NPs, using ultraviolet (UV) irradiation as a trigger. This is expected to allow drug release depending on patients' needs or physiological circumstances. Eleven formulations were arranged and their particle size, charge, and polydispersity were determined. The effect of CS-NPs size and the amount of TiO2-NPs, on the system collapse, was studied accordingly. Moreover, the collapse of these systems was examined using a fluorescence microscope after loading CS-NPs with Rhodamine. The formulations showed high monodispersity and had sizes ranged between 170 and 440 nm and charges ranged between +5 and +34 mV. Scanning electron microscope, Fourier-transform infrared spectroscopy, and X-ray diffraction proved the chemical deposition of TiO2-NPs on CS-NPs. The dye test showed that there are two factors that oppose each other and affected the deposition of TiO2-NPs on CS-NPs, the size of CS-NPs, and the amount of TiO2-NPs used. In addition, the dye test showed that the deposition of TiO2-NPs is a saturated process that relies on the amount of TiO2-NPs used initially. Finally, the intensity of Rhodamine released from these systems after illumination with UV light was related to the amount of TiO2-NPs deposited on CS-NPs. In conclusion, functionalization of CS-NPs with TiO2-NPs can be controlled and used to rupture CS-NPs on demand by illumination with UV light.Nusaiba Al-NemrawiSukaina NimrawiWolters Kluwer Medknow Publicationsarticlechitosan nanoparticlesrhodaminetitanium dioxide nanoparticlesultraviolet irradiationTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Advanced Pharmaceutical Technology & Research, Vol 12, Iss 4, Pp 402-407 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan nanoparticles rhodamine titanium dioxide nanoparticles ultraviolet irradiation Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	chitosan nanoparticles rhodamine titanium dioxide nanoparticles ultraviolet irradiation Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Nusaiba Al-Nemrawi Sukaina Nimrawi A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
description	Herein, chitosan nanoparticles (CS-NPs) were prepared and functionalized chemically with titanium dioxide nanoparticles (TiO2-NPs) to allow on-demand degradation of CS-NPs, using ultraviolet (UV) irradiation as a trigger. This is expected to allow drug release depending on patients' needs or physiological circumstances. Eleven formulations were arranged and their particle size, charge, and polydispersity were determined. The effect of CS-NPs size and the amount of TiO2-NPs, on the system collapse, was studied accordingly. Moreover, the collapse of these systems was examined using a fluorescence microscope after loading CS-NPs with Rhodamine. The formulations showed high monodispersity and had sizes ranged between 170 and 440 nm and charges ranged between +5 and +34 mV. Scanning electron microscope, Fourier-transform infrared spectroscopy, and X-ray diffraction proved the chemical deposition of TiO2-NPs on CS-NPs. The dye test showed that there are two factors that oppose each other and affected the deposition of TiO2-NPs on CS-NPs, the size of CS-NPs, and the amount of TiO2-NPs used. In addition, the dye test showed that the deposition of TiO2-NPs is a saturated process that relies on the amount of TiO2-NPs used initially. Finally, the intensity of Rhodamine released from these systems after illumination with UV light was related to the amount of TiO2-NPs deposited on CS-NPs. In conclusion, functionalization of CS-NPs with TiO2-NPs can be controlled and used to rupture CS-NPs on demand by illumination with UV light.
format	article
author	Nusaiba Al-Nemrawi Sukaina Nimrawi
author_facet	Nusaiba Al-Nemrawi Sukaina Nimrawi
author_sort	Nusaiba Al-Nemrawi
title	A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
title_short	A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
title_full	A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
title_fullStr	A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
title_full_unstemmed	A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
title_sort	novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/bd10afb818c045968e334a0ad5077b37
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A novel formulation of chitosan nanoparticles functionalized with titanium dioxide nanoparticles

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