A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.

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Autores principales:	Gourish Mondal, Meredith Stevers, Benjamin Goode, Alan Ashworth, David A. Solomon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd142773bd634488bdd09820a09ed0b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:bd142773bd634488bdd09820a09ed0b22021-12-02T14:39:01ZA requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers10.1038/s41467-019-09659-z2041-1723https://doaj.org/article/bd142773bd634488bdd09820a09ed0b22019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09659-zhttps://doaj.org/toc/2041-1723Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.Gourish MondalMeredith SteversBenjamin GoodeAlan AshworthDavid A. SolomonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gourish Mondal Meredith Stevers Benjamin Goode Alan Ashworth David A. Solomon A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
description	Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.
format	article
author	Gourish Mondal Meredith Stevers Benjamin Goode Alan Ashworth David A. Solomon
author_facet	Gourish Mondal Meredith Stevers Benjamin Goode Alan Ashworth David A. Solomon
author_sort	Gourish Mondal
title	A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
title_short	A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
title_full	A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
title_fullStr	A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
title_full_unstemmed	A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
title_sort	requirement for stag2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bd142773bd634488bdd09820a09ed0b2
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A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

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