A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.

Guardado en:
Detalles Bibliográficos
Autores principales: Gourish Mondal, Meredith Stevers, Benjamin Goode, Alan Ashworth, David A. Solomon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/bd142773bd634488bdd09820a09ed0b2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares