Regulatory mechanisms of incomplete huntingtin mRNA splicing

Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.

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Detalles Bibliográficos
Autores principales:	Andreas Neueder, Anaelle A. Dumas, Agnesska C. Benjamin, Gillian P. Bates
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd15556f976d414a8586ab29954b52a8
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spelling	oai:doaj.org-article:bd15556f976d414a8586ab29954b52a82021-12-02T16:50:08ZRegulatory mechanisms of incomplete huntingtin mRNA splicing10.1038/s41467-018-06281-32041-1723https://doaj.org/article/bd15556f976d414a8586ab29954b52a82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06281-3https://doaj.org/toc/2041-1723Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.Andreas NeuederAnaelle A. DumasAgnesska C. BenjaminGillian P. BatesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas Neueder Anaelle A. Dumas Agnesska C. Benjamin Gillian P. Bates Regulatory mechanisms of incomplete huntingtin mRNA splicing
description	Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process.
format	article
author	Andreas Neueder Anaelle A. Dumas Agnesska C. Benjamin Gillian P. Bates
author_facet	Andreas Neueder Anaelle A. Dumas Agnesska C. Benjamin Gillian P. Bates
author_sort	Andreas Neueder
title	Regulatory mechanisms of incomplete huntingtin mRNA splicing
title_short	Regulatory mechanisms of incomplete huntingtin mRNA splicing
title_full	Regulatory mechanisms of incomplete huntingtin mRNA splicing
title_fullStr	Regulatory mechanisms of incomplete huntingtin mRNA splicing
title_full_unstemmed	Regulatory mechanisms of incomplete huntingtin mRNA splicing
title_sort	regulatory mechanisms of incomplete huntingtin mrna splicing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bd15556f976d414a8586ab29954b52a8
work_keys_str_mv	AT andreasneueder regulatorymechanismsofincompletehuntingtinmrnasplicing AT anaelleadumas regulatorymechanismsofincompletehuntingtinmrnasplicing AT agnesskacbenjamin regulatorymechanismsofincompletehuntingtinmrnasplicing AT gillianpbates regulatorymechanismsofincompletehuntingtinmrnasplicing
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Regulatory mechanisms of incomplete huntingtin mRNA splicing

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