Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes

Abstract Previous studies exploring the influence of glycemic variability (GV) on the pathogenesis of distal symmetrical polyneuropathy (DSPN) in type 1 diabetes (T1DM) produced conflicting results. The aim of this study was to assess the relationship between GV and DSPN in T1DM. Adults with T1DM we...

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Autores principales:	Ziyang Shen, Hemin Jiang, Rong Huang, Yunting Zhou, Qian Li, Jianhua Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd1586c091a3494eab94fda4beba1932
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spelling	oai:doaj.org-article:bd1586c091a3494eab94fda4beba19322021-11-28T12:21:55ZAssociation of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes10.1038/s41598-021-02258-32045-2322https://doaj.org/article/bd1586c091a3494eab94fda4beba19322021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02258-3https://doaj.org/toc/2045-2322Abstract Previous studies exploring the influence of glycemic variability (GV) on the pathogenesis of distal symmetrical polyneuropathy (DSPN) in type 1 diabetes (T1DM) produced conflicting results. The aim of this study was to assess the relationship between GV and DSPN in T1DM. Adults with T1DM were included in this cross-sectional study and asked to undergo 3-day CGM. GV quantified by coefficient of variation (CV) and mean amplitude of glucose excursions (MAGE) were obtained from CGM. Clinical characteristics and biochemical assessments were collected for analysis. The study comprised 152 T1DM patients (53.9% males) with mean age of 44.2 year. Higher levels of age and duration of diabetes and lower levels of total cholesterol, LDL, fasting C-peptide and postprandial C-peptide were observed in DSPN subjects. DSPN groups displayed a higher blood glucose between 00:00 and 12:59 according to the CGM profile. Higher MAGE and CV were associated with increased risk of DSPN in the fully adjusted model. Meanwhile, a significant association between measurements of hypoglycemia, especially nocturnal hypoglycemia, and DSPN was found after multiple tests. CGM parameters describing the glycemic variability and hypoglycemia were potential risk factors for DSPN in adults with T1DM.Ziyang ShenHemin JiangRong HuangYunting ZhouQian LiJianhua MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ziyang Shen Hemin Jiang Rong Huang Yunting Zhou Qian Li Jianhua Ma Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
description	Abstract Previous studies exploring the influence of glycemic variability (GV) on the pathogenesis of distal symmetrical polyneuropathy (DSPN) in type 1 diabetes (T1DM) produced conflicting results. The aim of this study was to assess the relationship between GV and DSPN in T1DM. Adults with T1DM were included in this cross-sectional study and asked to undergo 3-day CGM. GV quantified by coefficient of variation (CV) and mean amplitude of glucose excursions (MAGE) were obtained from CGM. Clinical characteristics and biochemical assessments were collected for analysis. The study comprised 152 T1DM patients (53.9% males) with mean age of 44.2 year. Higher levels of age and duration of diabetes and lower levels of total cholesterol, LDL, fasting C-peptide and postprandial C-peptide were observed in DSPN subjects. DSPN groups displayed a higher blood glucose between 00:00 and 12:59 according to the CGM profile. Higher MAGE and CV were associated with increased risk of DSPN in the fully adjusted model. Meanwhile, a significant association between measurements of hypoglycemia, especially nocturnal hypoglycemia, and DSPN was found after multiple tests. CGM parameters describing the glycemic variability and hypoglycemia were potential risk factors for DSPN in adults with T1DM.
format	article
author	Ziyang Shen Hemin Jiang Rong Huang Yunting Zhou Qian Li Jianhua Ma
author_facet	Ziyang Shen Hemin Jiang Rong Huang Yunting Zhou Qian Li Jianhua Ma
author_sort	Ziyang Shen
title	Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
title_short	Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
title_full	Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
title_fullStr	Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
title_full_unstemmed	Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
title_sort	association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd1586c091a3494eab94fda4beba1932
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Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes

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