Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic and right-hand twisted, which differs from in vitro gene...

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Autores principales:	Marius Kollmer, William Close, Leonie Funk, Jay Rasmussen, Aref Bsoul, Angelika Schierhorn, Matthias Schmidt, Christina J. Sigurdson, Mathias Jucker, Marcus Fändrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd15cbb55e35470c93b5f854aad34b44
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spelling	oai:doaj.org-article:bd15cbb55e35470c93b5f854aad34b442021-12-02T14:39:40ZCryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue10.1038/s41467-019-12683-82041-1723https://doaj.org/article/bd15cbb55e35470c93b5f854aad34b442019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12683-8https://doaj.org/toc/2041-1723Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic and right-hand twisted, which differs from in vitro generated Aβ fibrils.Marius KollmerWilliam CloseLeonie FunkJay RasmussenAref BsoulAngelika SchierhornMatthias SchmidtChristina J. SigurdsonMathias JuckerMarcus FändrichNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marius Kollmer William Close Leonie Funk Jay Rasmussen Aref Bsoul Angelika Schierhorn Matthias Schmidt Christina J. Sigurdson Mathias Jucker Marcus Fändrich Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
description	Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic and right-hand twisted, which differs from in vitro generated Aβ fibrils.
format	article
author	Marius Kollmer William Close Leonie Funk Jay Rasmussen Aref Bsoul Angelika Schierhorn Matthias Schmidt Christina J. Sigurdson Mathias Jucker Marcus Fändrich
author_facet	Marius Kollmer William Close Leonie Funk Jay Rasmussen Aref Bsoul Angelika Schierhorn Matthias Schmidt Christina J. Sigurdson Mathias Jucker Marcus Fändrich
author_sort	Marius Kollmer
title	Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
title_short	Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
title_full	Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
title_fullStr	Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
title_full_unstemmed	Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
title_sort	cryo-em structure and polymorphism of aβ amyloid fibrils purified from alzheimer’s brain tissue
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bd15cbb55e35470c93b5f854aad34b44
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Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

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