Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate...

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Autores principales:	Michael Dietachmayr, Abirami Rathakrishnan, Oleksandra Karpiuk, Felix von Zweydorf, Thomas Engleitner, Vanesa Fernández-Sáiz, Petra Schenk, Marius Ueffing, Roland Rad, Martin Eilers, Christian Johannes Gloeckner, Katharina Clemm von Hohenberg, Florian Bassermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd16efa5decb42a998a0892197a13545
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spelling	oai:doaj.org-article:bd16efa5decb42a998a0892197a135452021-12-02T14:41:04ZAntagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival10.1038/s41467-020-15059-52041-1723https://doaj.org/article/bd16efa5decb42a998a0892197a135452020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15059-5https://doaj.org/toc/2041-1723In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate mitotic survival.Michael DietachmayrAbirami RathakrishnanOleksandra KarpiukFelix von ZweydorfThomas EngleitnerVanesa Fernández-SáizPetra SchenkMarius UeffingRoland RadMartin EilersChristian Johannes GloecknerKatharina Clemm von HohenbergFlorian BassermannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Dietachmayr Abirami Rathakrishnan Oleksandra Karpiuk Felix von Zweydorf Thomas Engleitner Vanesa Fernández-Sáiz Petra Schenk Marius Ueffing Roland Rad Martin Eilers Christian Johannes Gloeckner Katharina Clemm von Hohenberg Florian Bassermann Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
description	In yeast, the phosphatase Cdc14 controls mitotic exit. Here the authors show that mammalian CDC14B antagonizes CDK1, to keep the deubiquitinase USP9X unphosphorylated and inactive, and that Wilms’ tumor protein 1 is a substrate for active USP9X that directs mitosis-specific transcription to regulate mitotic survival.
format	article
author	Michael Dietachmayr Abirami Rathakrishnan Oleksandra Karpiuk Felix von Zweydorf Thomas Engleitner Vanesa Fernández-Sáiz Petra Schenk Marius Ueffing Roland Rad Martin Eilers Christian Johannes Gloeckner Katharina Clemm von Hohenberg Florian Bassermann
author_facet	Michael Dietachmayr Abirami Rathakrishnan Oleksandra Karpiuk Felix von Zweydorf Thomas Engleitner Vanesa Fernández-Sáiz Petra Schenk Marius Ueffing Roland Rad Martin Eilers Christian Johannes Gloeckner Katharina Clemm von Hohenberg Florian Bassermann
author_sort	Michael Dietachmayr
title	Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
title_short	Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
title_full	Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
title_fullStr	Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
title_full_unstemmed	Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival
title_sort	antagonistic activities of cdc14b and cdk1 on usp9x regulate wt1-dependent mitotic transcription and survival
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bd16efa5decb42a998a0892197a13545
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Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

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