Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops that are more toxic to the cell by causing DNA da...

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Autores principales:	Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac
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spelling	oai:doaj.org-article:bd1932962b864455ac3b032015f1a0ac2021-12-02T17:06:35ZTopoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites10.1038/s41467-020-17858-22041-1723https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17858-2https://doaj.org/toc/2041-1723While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops that are more toxic to the cell by causing DNA damage.Alexy PromonetIsmaël PadioleauYaqun LiuLionel SanzAnna BiernackaAnne-Lyne SchmitzMagdalena SkrzypczakAmélie SarrazinClément MettlingMaga RowickaKrzysztof GinalskiFrédéric ChedinChun-Long ChenYea-Lih LinPhilippe PaseroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexy Promonet Ismaël Padioleau Yaqun Liu Lionel Sanz Anna Biernacka Anne-Lyne Schmitz Magdalena Skrzypczak Amélie Sarrazin Clément Mettling Maga Rowicka Krzysztof Ginalski Frédéric Chedin Chun-Long Chen Yea-Lih Lin Philippe Pasero Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
description	While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops that are more toxic to the cell by causing DNA damage.
format	article
author	Alexy Promonet Ismaël Padioleau Yaqun Liu Lionel Sanz Anna Biernacka Anne-Lyne Schmitz Magdalena Skrzypczak Amélie Sarrazin Clément Mettling Maga Rowicka Krzysztof Ginalski Frédéric Chedin Chun-Long Chen Yea-Lih Lin Philippe Pasero
author_facet	Alexy Promonet Ismaël Padioleau Yaqun Liu Lionel Sanz Anna Biernacka Anne-Lyne Schmitz Magdalena Skrzypczak Amélie Sarrazin Clément Mettling Maga Rowicka Krzysztof Ginalski Frédéric Chedin Chun-Long Chen Yea-Lih Lin Philippe Pasero
author_sort	Alexy Promonet
title	Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
title_short	Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
title_full	Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
title_fullStr	Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
title_full_unstemmed	Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
title_sort	topoisomerase 1 prevents replication stress at r-loop-enriched transcription termination sites
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac
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Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

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