Neurologic uses of botulinum neurotoxin type A

John P Ney, Kevin R JosephMadigan Army Medical Center, Neurology Service, Tacoma, WA, USAAbstract: This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Curren...

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Autores principales:	John P Ney, Kevin R Joseph
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bd19972e45e94d59811dee16cc73c4b8
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spelling	oai:doaj.org-article:bd19972e45e94d59811dee16cc73c4b82021-12-02T00:56:52ZNeurologic uses of botulinum neurotoxin type A1176-63281178-2021https://doaj.org/article/bd19972e45e94d59811dee16cc73c4b82007-01-01T00:00:00Zhttp://www.dovepress.com/neurologic-uses-of-botulinum-neurotoxin-type-a-a957https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021John P Ney, Kevin R JosephMadigan Army Medical Center, Neurology Service, Tacoma, WA, USAAbstract: This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.Keywords: botulinum neurotoxins, BOTOX&reg;, Dysport&reg;, chemodenervation John P NeyKevin R JosephDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2007, Iss Issue 6, Pp 785-798 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 John P Ney Kevin R Joseph Neurologic uses of botulinum neurotoxin type A
description	John P Ney, Kevin R JosephMadigan Army Medical Center, Neurology Service, Tacoma, WA, USAAbstract: This article reviews the current and most neurologic uses of botulinum neurotoxin type A (BoNT-A), beginning with relevant historical data, neurochemical mechanism at the neuromuscular junction. Current commercial preparations of BoNT-A are reviewed, as are immunologic issues relating to secondary failure of BoNT-A therapy. Clinical uses are summarized with an emphasis on controlled clinical trials (as appropriate), including facial movement disorders, focal neck and limb dystonias, spasticity, hypersecretory syndromes, and pain.Keywords: botulinum neurotoxins, BOTOX&reg;, Dysport&reg;, chemodenervation
format	article
author	John P Ney Kevin R Joseph
author_facet	John P Ney Kevin R Joseph
author_sort	John P Ney
title	Neurologic uses of botulinum neurotoxin type A
title_short	Neurologic uses of botulinum neurotoxin type A
title_full	Neurologic uses of botulinum neurotoxin type A
title_fullStr	Neurologic uses of botulinum neurotoxin type A
title_full_unstemmed	Neurologic uses of botulinum neurotoxin type A
title_sort	neurologic uses of botulinum neurotoxin type a
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/bd19972e45e94d59811dee16cc73c4b8
work_keys_str_mv	AT johnpney neurologicusesofbotulinumneurotoxintypea AT kevinrjoseph neurologicusesofbotulinumneurotoxintypea
_version_	1718403406194802688

Neurologic uses of botulinum neurotoxin type A

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