Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister stat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael Ramirez, Satwik Rajaram, Robert J. Steininger, Daria Osipchuk, Maike A. Roth, Leanna S. Morinishi, Louise Evans, Weiyue Ji, Chien-Hsiang Hsu, Kevin Thurley, Shuguang Wei, Anwu Zhou, Prasad R. Koduru, Bruce A. Posner, Lani F. Wu, Steven J. Altschuler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd1a3c50ad1a402d9bff233756a1c84e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bd1a3c50ad1a402d9bff233756a1c84e
record_format	dspace
spelling	oai:doaj.org-article:bd1a3c50ad1a402d9bff233756a1c84e2021-12-02T16:57:29ZDiverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells10.1038/ncomms106902041-1723https://doaj.org/article/bd1a3c50ad1a402d9bff233756a1c84e2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10690https://doaj.org/toc/2041-1723Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.Michael RamirezSatwik RajaramRobert J. SteiningerDaria OsipchukMaike A. RothLeanna S. MorinishiLouise EvansWeiyue JiChien-Hsiang HsuKevin ThurleyShuguang WeiAnwu ZhouPrasad R. KoduruBruce A. PosnerLani F. WuSteven J. AltschulerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Ramirez Satwik Rajaram Robert J. Steininger Daria Osipchuk Maike A. Roth Leanna S. Morinishi Louise Evans Weiyue Ji Chien-Hsiang Hsu Kevin Thurley Shuguang Wei Anwu Zhou Prasad R. Koduru Bruce A. Posner Lani F. Wu Steven J. Altschuler Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
description	Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
format	article
author	Michael Ramirez Satwik Rajaram Robert J. Steininger Daria Osipchuk Maike A. Roth Leanna S. Morinishi Louise Evans Weiyue Ji Chien-Hsiang Hsu Kevin Thurley Shuguang Wei Anwu Zhou Prasad R. Koduru Bruce A. Posner Lani F. Wu Steven J. Altschuler
author_facet	Michael Ramirez Satwik Rajaram Robert J. Steininger Daria Osipchuk Maike A. Roth Leanna S. Morinishi Louise Evans Weiyue Ji Chien-Hsiang Hsu Kevin Thurley Shuguang Wei Anwu Zhou Prasad R. Koduru Bruce A. Posner Lani F. Wu Steven J. Altschuler
author_sort	Michael Ramirez
title	Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
title_short	Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
title_full	Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
title_fullStr	Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
title_full_unstemmed	Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
title_sort	diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bd1a3c50ad1a402d9bff233756a1c84e
work_keys_str_mv	AT michaelramirez diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT satwikrajaram diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT robertjsteininger diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT dariaosipchuk diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT maikearoth diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT leannasmorinishi diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT louiseevans diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT weiyueji diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT chienhsianghsu diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT kevinthurley diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT shuguangwei diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT anwuzhou diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT prasadrkoduru diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT bruceaposner diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT lanifwu diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells AT stevenjaltschuler diversedrugresistancemechanismscanemergefromdrugtolerantcancerpersistercells
_version_	1718382587247853568

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Ejemplares similares