Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic.
We compared the neutralization sensitivity of early/transmitted HIV-1 variants from patients infected by subtype B viruses at 3 periods of the epidemic (1987-1991, 1996-2000, 2006-2010). Infectious pseudotyped viruses expressing envelope glycoproteins representative of the viral quasi-species infect...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/bd1a76f46f934f25976565084f923d4c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:bd1a76f46f934f25976565084f923d4c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:bd1a76f46f934f25976565084f923d4c2021-11-18T06:05:25ZEvidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic.1553-73661553-737410.1371/journal.ppat.1003477https://doaj.org/article/bd1a76f46f934f25976565084f923d4c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23853594/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374We compared the neutralization sensitivity of early/transmitted HIV-1 variants from patients infected by subtype B viruses at 3 periods of the epidemic (1987-1991, 1996-2000, 2006-2010). Infectious pseudotyped viruses expressing envelope glycoproteins representative of the viral quasi-species infecting each patient were tested for sensitivity to neutralization by pools of sera from HIV-1 chronically infected patients and by an updated panel of 13 human monoclonal neutralizing antibodies (HuMoNAbs). A progressive significantly enhanced resistance to neutralization was observed over calendar time, by both human sera and most of the HuMoNAbs tested (b12, VRC01, VRC03, NIH45-46(G54W), PG9, PG16, PGT121, PGT128, PGT145). Despite this evolution, a combination of two HuMoNAbs (NIH45-46(G54W) and PGT128) still would efficiently neutralize the most contemporary transmitted variants. In addition, we observed a significant reduction of the heterologous neutralizing activity of sera from individuals infected most recently (2003-2007) compared to patients infected earlier (1987-1991), suggesting that the increasing resistance of the HIV species to neutralization over time coincided with a decreased immunogenicity. These data provide evidence for an ongoing adaptation of the HIV-1 species to the humoral immunity of the human population, which may add an additional obstacle to the design of an efficient HIV-1 vaccine.Mélanie Bouvin-PleyMarion MorgandAlain MoreauPauline JestinClaire SimonnetLaurent TranCécile GoujardLaurence MeyerFrancis BarinMartine BraibantPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 7, p e1003477 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Mélanie Bouvin-Pley Marion Morgand Alain Moreau Pauline Jestin Claire Simonnet Laurent Tran Cécile Goujard Laurence Meyer Francis Barin Martine Braibant Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| description |
We compared the neutralization sensitivity of early/transmitted HIV-1 variants from patients infected by subtype B viruses at 3 periods of the epidemic (1987-1991, 1996-2000, 2006-2010). Infectious pseudotyped viruses expressing envelope glycoproteins representative of the viral quasi-species infecting each patient were tested for sensitivity to neutralization by pools of sera from HIV-1 chronically infected patients and by an updated panel of 13 human monoclonal neutralizing antibodies (HuMoNAbs). A progressive significantly enhanced resistance to neutralization was observed over calendar time, by both human sera and most of the HuMoNAbs tested (b12, VRC01, VRC03, NIH45-46(G54W), PG9, PG16, PGT121, PGT128, PGT145). Despite this evolution, a combination of two HuMoNAbs (NIH45-46(G54W) and PGT128) still would efficiently neutralize the most contemporary transmitted variants. In addition, we observed a significant reduction of the heterologous neutralizing activity of sera from individuals infected most recently (2003-2007) compared to patients infected earlier (1987-1991), suggesting that the increasing resistance of the HIV species to neutralization over time coincided with a decreased immunogenicity. These data provide evidence for an ongoing adaptation of the HIV-1 species to the humoral immunity of the human population, which may add an additional obstacle to the design of an efficient HIV-1 vaccine. |
| format |
article |
| author |
Mélanie Bouvin-Pley Marion Morgand Alain Moreau Pauline Jestin Claire Simonnet Laurent Tran Cécile Goujard Laurence Meyer Francis Barin Martine Braibant |
| author_facet |
Mélanie Bouvin-Pley Marion Morgand Alain Moreau Pauline Jestin Claire Simonnet Laurent Tran Cécile Goujard Laurence Meyer Francis Barin Martine Braibant |
| author_sort |
Mélanie Bouvin-Pley |
| title |
Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| title_short |
Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| title_full |
Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| title_fullStr |
Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| title_full_unstemmed |
Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| title_sort |
evidence for a continuous drift of the hiv-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/bd1a76f46f934f25976565084f923d4c |
| work_keys_str_mv |
AT melaniebouvinpley evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT marionmorgand evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT alainmoreau evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT paulinejestin evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT clairesimonnet evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT laurenttran evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT cecilegoujard evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT laurencemeyer evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT francisbarin evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic AT martinebraibant evidenceforacontinuousdriftofthehiv1speciestowardshigherresistancetoneutralizingantibodiesoverthecourseoftheepidemic |
| _version_ |
1718424629946613760 |