Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis

Abstract Patients with ulcerative colitis are typically suspected of an inflammatory flare based on suggestive symptoms of inflammation. The aim of this study was to evaluate the impact of inflammation on colonic motility and rectal sensitivity from active to recovery of inflammation. Male rats were...

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Autores principales:	Yan Chen, Yu Guo, Payam Gharibani, Jie Chen, Florin M. Selaru, Jiande D. Z. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd1bd660241f45fba680504e583ecb1a
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spelling	oai:doaj.org-article:bd1bd660241f45fba680504e583ecb1a2021-12-02T14:27:56ZTransitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis10.1038/s41598-021-87814-72045-2322https://doaj.org/article/bd1bd660241f45fba680504e583ecb1a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87814-7https://doaj.org/toc/2045-2322Abstract Patients with ulcerative colitis are typically suspected of an inflammatory flare based on suggestive symptoms of inflammation. The aim of this study was to evaluate the impact of inflammation on colonic motility and rectal sensitivity from active to recovery of inflammation. Male rats were given drinking water with 5% dextran sulfate sodium for 7 days. Inflammation, intestinal motor and sensory functions were investigated weekly for 6 weeks. (1) The disease activity index score, fecal calprotectin and tumor necrosis factor alpha were increased from Day 0 to Day 7 (active inflammation) and then decreased gradually until recovery. (2) Distal colon transit was accelerated on Day 7, and then remained unchanged. Whole gut transit was delayed on Day 7 but accelerated from Day 14 to Day 42. (3) Rectal compliance was unaffected from Day 0 to Day 7, but decreased afterwards. (4) Rectal hypersensitivity was noted on Day 7 and persistent. (5) Plasma acetylcholine was decreased on Day 7 but increased from Day 14 to Day 42. Nerve growth factor was increased from Day 7 to Day 42. DSS-induced inflammation leads to visceral hypersensitivity that is sustained until the resolution of inflammation, probably mediated by NGF. Rectal compliance is reduced one week after the DSS-induced inflammation and the reduction is sustained until the resolution of inflammation. Gastrointestinal transit is also altered during and after active colonic inflammation.Yan ChenYu GuoPayam GharibaniJie ChenFlorin M. SelaruJiande D. Z. ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Chen Yu Guo Payam Gharibani Jie Chen Florin M. Selaru Jiande D. Z. Chen Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
description	Abstract Patients with ulcerative colitis are typically suspected of an inflammatory flare based on suggestive symptoms of inflammation. The aim of this study was to evaluate the impact of inflammation on colonic motility and rectal sensitivity from active to recovery of inflammation. Male rats were given drinking water with 5% dextran sulfate sodium for 7 days. Inflammation, intestinal motor and sensory functions were investigated weekly for 6 weeks. (1) The disease activity index score, fecal calprotectin and tumor necrosis factor alpha were increased from Day 0 to Day 7 (active inflammation) and then decreased gradually until recovery. (2) Distal colon transit was accelerated on Day 7, and then remained unchanged. Whole gut transit was delayed on Day 7 but accelerated from Day 14 to Day 42. (3) Rectal compliance was unaffected from Day 0 to Day 7, but decreased afterwards. (4) Rectal hypersensitivity was noted on Day 7 and persistent. (5) Plasma acetylcholine was decreased on Day 7 but increased from Day 14 to Day 42. Nerve growth factor was increased from Day 7 to Day 42. DSS-induced inflammation leads to visceral hypersensitivity that is sustained until the resolution of inflammation, probably mediated by NGF. Rectal compliance is reduced one week after the DSS-induced inflammation and the reduction is sustained until the resolution of inflammation. Gastrointestinal transit is also altered during and after active colonic inflammation.
format	article
author	Yan Chen Yu Guo Payam Gharibani Jie Chen Florin M. Selaru Jiande D. Z. Chen
author_facet	Yan Chen Yu Guo Payam Gharibani Jie Chen Florin M. Selaru Jiande D. Z. Chen
author_sort	Yan Chen
title	Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
title_short	Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
title_full	Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
title_fullStr	Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
title_full_unstemmed	Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
title_sort	transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd1bd660241f45fba680504e583ecb1a
work_keys_str_mv	AT yanchen transitionalchangesingastrointestinaltransitandrectalsensitivityfromactivetorecoveryofinflammationinarodentmodelofcolitis AT yuguo transitionalchangesingastrointestinaltransitandrectalsensitivityfromactivetorecoveryofinflammationinarodentmodelofcolitis AT payamgharibani transitionalchangesingastrointestinaltransitandrectalsensitivityfromactivetorecoveryofinflammationinarodentmodelofcolitis AT jiechen transitionalchangesingastrointestinaltransitandrectalsensitivityfromactivetorecoveryofinflammationinarodentmodelofcolitis AT florinmselaru transitionalchangesingastrointestinaltransitandrectalsensitivityfromactivetorecoveryofinflammationinarodentmodelofcolitis AT jiandedzchen transitionalchangesingastrointestinaltransitandrectalsensitivityfromactivetorecoveryofinflammationinarodentmodelofcolitis
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Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis

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