Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy
Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.
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Nature Portfolio
2021
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oai:doaj.org-article:bd1fa646273840d68762f26fc8a370472021-11-14T12:35:03ZInterferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy10.1038/s41467-021-26880-x2041-1723https://doaj.org/article/bd1fa646273840d68762f26fc8a370472021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26880-xhttps://doaj.org/toc/2041-1723Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.Matthias KettwigKatharina TernkaKristin WendlandDennis Manfred KrügerSilvia ZamparCharlotte SchobJonas FranzAbhishek AichAnne WinklerM. Sadman SakibLalit KauraniRobert EppleHauke B. WernerSamy HakroushJulia KitzMarco PrinzEva BartokGunther HartmannSimone SchröderPeter RehlingMarco HennekeSusann BoretiusA. AliaOliver WirthsAndre FischerChristine StadelmannStefan NesslerJutta GärtnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
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| topic |
Science Q |
| spellingShingle |
Science Q Matthias Kettwig Katharina Ternka Kristin Wendland Dennis Manfred Krüger Silvia Zampar Charlotte Schob Jonas Franz Abhishek Aich Anne Winkler M. Sadman Sakib Lalit Kaurani Robert Epple Hauke B. Werner Samy Hakroush Julia Kitz Marco Prinz Eva Bartok Gunther Hartmann Simone Schröder Peter Rehling Marco Henneke Susann Boretius A. Alia Oliver Wirths Andre Fischer Christine Stadelmann Stefan Nessler Jutta Gärtner Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| description |
Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent. |
| format |
article |
| author |
Matthias Kettwig Katharina Ternka Kristin Wendland Dennis Manfred Krüger Silvia Zampar Charlotte Schob Jonas Franz Abhishek Aich Anne Winkler M. Sadman Sakib Lalit Kaurani Robert Epple Hauke B. Werner Samy Hakroush Julia Kitz Marco Prinz Eva Bartok Gunther Hartmann Simone Schröder Peter Rehling Marco Henneke Susann Boretius A. Alia Oliver Wirths Andre Fischer Christine Stadelmann Stefan Nessler Jutta Gärtner |
| author_facet |
Matthias Kettwig Katharina Ternka Kristin Wendland Dennis Manfred Krüger Silvia Zampar Charlotte Schob Jonas Franz Abhishek Aich Anne Winkler M. Sadman Sakib Lalit Kaurani Robert Epple Hauke B. Werner Samy Hakroush Julia Kitz Marco Prinz Eva Bartok Gunther Hartmann Simone Schröder Peter Rehling Marco Henneke Susann Boretius A. Alia Oliver Wirths Andre Fischer Christine Stadelmann Stefan Nessler Jutta Gärtner |
| author_sort |
Matthias Kettwig |
| title |
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| title_short |
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| title_full |
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| title_fullStr |
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| title_full_unstemmed |
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy |
| title_sort |
interferon-driven brain phenotype in a mouse model of rnaset2 deficient leukoencephalopathy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bd1fa646273840d68762f26fc8a37047 |
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