The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction

Introduction: Hypertension is the most common risk factor for heart failure causing an increase in N-Terminal-Pro Brain Natriuretic Peptide (NT-proBNP) level and a decrease in left ventricular ejection fraction (LVEF). Objective: To investigate the effect of hypertension on NT-proBNP level and LVEF...

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Autores principales:	Kati Sriwiyati, Taufiqurrachman Nasihun, M. Saugi Abduh
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2019
Materias:	hypertension stage, nt-probnp, left ventricular ejection fraction, chronic heart failure Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bd21f4b4a3ae4f9391f711eb65d58230
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spelling	oai:doaj.org-article:bd21f4b4a3ae4f9391f711eb65d582302021-11-25T13:16:18ZThe Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction2085-15452339-093Xhttps://doaj.org/article/bd21f4b4a3ae4f9391f711eb65d582302019-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/3379https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIntroduction: Hypertension is the most common risk factor for heart failure causing an increase in N-Terminal-Pro Brain Natriuretic Peptide (NT-proBNP) level and a decrease in left ventricular ejection fraction (LVEF). Objective: To investigate the effect of hypertension on NT-proBNP level and LVEF in patients with chronic heart failure. Methods: This cross sectional study takes 29 people with hypertension stage-1 (HTD-1) and 27 people with hypertension stage-2 (HTD-2) as sample. The left ventricular ejection fraction and NT-proBNP level obtained from medical records are analyzed using independent t test and Mann Withney test, followed with Spearmen correlation between NT-proBNP level and LVEF. Results: Mann-Whitney test indicates that the mean value of NT-proBNP level of HTD-2 is significantly higher compared to that of HTD-1, p = 0,000. On the contrary, the independent t test shows that LVEF in HTD-2 is lower than that of HDT-1, p = 0.001. The Spearman correlation analysis conducted on the NT-proBNP level and the LVEF results in value of -0.651, p = 0.000. The cut-off-point value of NT-proBNP level is 1511pg/ml (sensitivity 0.82% and specificity 0.80%) and the value of area under the ROC curve > 0.7. The left ventricular ejection fraction has an area under the ROC curve > 0.7 with a cut-off-point value of 39% (sensitivity 0.67% and specificity 0.69%). Conclusion: The NT-proBNP level and the LVEF of HTD-2 are significant higher and lower respectively compared to those of HTD-1. The NT-proBNP level and LVEF also show a strong negative correlation. The cut-off-point value of NT-proBNP level and LVEF can be utilized to compare the stages of hypertension in patients with chronic heart failure.Kati SriwiyatiTaufiqurrachman NasihunM. Saugi AbduhUniversitas Sultan Agung Semarangarticlehypertension stage, nt-probnp, left ventricular ejection fraction, chronic heart failureMedicine (General)R5-920ENSains Medika, Vol 10, Iss 1, Pp 5-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension stage, nt-probnp, left ventricular ejection fraction, chronic heart failure Medicine (General) R5-920
spellingShingle	hypertension stage, nt-probnp, left ventricular ejection fraction, chronic heart failure Medicine (General) R5-920 Kati Sriwiyati Taufiqurrachman Nasihun M. Saugi Abduh The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction
description	Introduction: Hypertension is the most common risk factor for heart failure causing an increase in N-Terminal-Pro Brain Natriuretic Peptide (NT-proBNP) level and a decrease in left ventricular ejection fraction (LVEF). Objective: To investigate the effect of hypertension on NT-proBNP level and LVEF in patients with chronic heart failure. Methods: This cross sectional study takes 29 people with hypertension stage-1 (HTD-1) and 27 people with hypertension stage-2 (HTD-2) as sample. The left ventricular ejection fraction and NT-proBNP level obtained from medical records are analyzed using independent t test and Mann Withney test, followed with Spearmen correlation between NT-proBNP level and LVEF. Results: Mann-Whitney test indicates that the mean value of NT-proBNP level of HTD-2 is significantly higher compared to that of HTD-1, p = 0,000. On the contrary, the independent t test shows that LVEF in HTD-2 is lower than that of HDT-1, p = 0.001. The Spearman correlation analysis conducted on the NT-proBNP level and the LVEF results in value of -0.651, p = 0.000. The cut-off-point value of NT-proBNP level is 1511pg/ml (sensitivity 0.82% and specificity 0.80%) and the value of area under the ROC curve > 0.7. The left ventricular ejection fraction has an area under the ROC curve > 0.7 with a cut-off-point value of 39% (sensitivity 0.67% and specificity 0.69%). Conclusion: The NT-proBNP level and the LVEF of HTD-2 are significant higher and lower respectively compared to those of HTD-1. The NT-proBNP level and LVEF also show a strong negative correlation. The cut-off-point value of NT-proBNP level and LVEF can be utilized to compare the stages of hypertension in patients with chronic heart failure.
format	article
author	Kati Sriwiyati Taufiqurrachman Nasihun M. Saugi Abduh
author_facet	Kati Sriwiyati Taufiqurrachman Nasihun M. Saugi Abduh
author_sort	Kati Sriwiyati
title	The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction
title_short	The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction
title_full	The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction
title_fullStr	The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction
title_full_unstemmed	The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction
title_sort	effects of hypertension stages on n-terminal-pro brain natriuretic peptide (nt-pro-bnp) level and left ventricular ejection fraction
publisher	Universitas Sultan Agung Semarang
publishDate	2019
url	https://doaj.org/article/bd21f4b4a3ae4f9391f711eb65d58230
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The Effects of Hypertension Stages on N-Terminal-Pro Brain Natriuretic Peptide (NT-Pro-BNP) Level and Left Ventricular Ejection Fraction

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