Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.

Drosophila larval hematopoiesis occurs in a specialized multi-lobed organ called the lymph gland. Extensive characterization of the organ has provided mechanistic insights into events related to developmental hematopoiesis. Spanning from the thoracic to the abdominal segment of the larvae, this orga...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aditya Kanwal, Pranav Vijay Joshi, Sudip Mandal, Lolitika Mandal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/bd23c4eeb9cb466cb7a5b711417014ad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bd23c4eeb9cb466cb7a5b711417014ad
record_format	dspace
spelling	oai:doaj.org-article:bd23c4eeb9cb466cb7a5b711417014ad2021-12-02T20:03:23ZUbx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.1553-73901553-740410.1371/journal.pgen.1009709https://doaj.org/article/bd23c4eeb9cb466cb7a5b711417014ad2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009709https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Drosophila larval hematopoiesis occurs in a specialized multi-lobed organ called the lymph gland. Extensive characterization of the organ has provided mechanistic insights into events related to developmental hematopoiesis. Spanning from the thoracic to the abdominal segment of the larvae, this organ comprises a pair of primary, secondary, and tertiary lobes. Much of our understanding arises from the studies on the primary lobe, while the secondary and tertiary lobes have remained mostly unexplored. Previous studies have inferred that these lobes are composed of progenitors that differentiate during pupation; however, the mechanistic basis of this extended progenitor state remains unclear. This study shows that posterior lobe progenitors are maintained by a local signaling center defined by Ubx and Collier in the tertiary lobe. This Ubx zone in the tertiary lobe shares several markers with the niche of the primary lobe. Ubx domain regulates the homeostasis of the posterior lobe progenitors in normal development and an immune-challenged scenario. Our study establishes the lymph gland as a model to tease out how the progenitors interface with the dual niches within an organ during development and disorders.Aditya KanwalPranav Vijay JoshiSudip MandalLolitika MandalPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 8, p e1009709 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Aditya Kanwal Pranav Vijay Joshi Sudip Mandal Lolitika Mandal Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
description	Drosophila larval hematopoiesis occurs in a specialized multi-lobed organ called the lymph gland. Extensive characterization of the organ has provided mechanistic insights into events related to developmental hematopoiesis. Spanning from the thoracic to the abdominal segment of the larvae, this organ comprises a pair of primary, secondary, and tertiary lobes. Much of our understanding arises from the studies on the primary lobe, while the secondary and tertiary lobes have remained mostly unexplored. Previous studies have inferred that these lobes are composed of progenitors that differentiate during pupation; however, the mechanistic basis of this extended progenitor state remains unclear. This study shows that posterior lobe progenitors are maintained by a local signaling center defined by Ubx and Collier in the tertiary lobe. This Ubx zone in the tertiary lobe shares several markers with the niche of the primary lobe. Ubx domain regulates the homeostasis of the posterior lobe progenitors in normal development and an immune-challenged scenario. Our study establishes the lymph gland as a model to tease out how the progenitors interface with the dual niches within an organ during development and disorders.
format	article
author	Aditya Kanwal Pranav Vijay Joshi Sudip Mandal Lolitika Mandal
author_facet	Aditya Kanwal Pranav Vijay Joshi Sudip Mandal Lolitika Mandal
author_sort	Aditya Kanwal
title	Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
title_short	Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
title_full	Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
title_fullStr	Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
title_full_unstemmed	Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.
title_sort	ubx-collier signaling cascade maintains blood progenitors in the posterior lobes of the drosophila larval lymph gland.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bd23c4eeb9cb466cb7a5b711417014ad
work_keys_str_mv	AT adityakanwal ubxcolliersignalingcascademaintainsbloodprogenitorsintheposteriorlobesofthedrosophilalarvallymphgland AT pranavvijayjoshi ubxcolliersignalingcascademaintainsbloodprogenitorsintheposteriorlobesofthedrosophilalarvallymphgland AT sudipmandal ubxcolliersignalingcascademaintainsbloodprogenitorsintheposteriorlobesofthedrosophilalarvallymphgland AT lolitikamandal ubxcolliersignalingcascademaintainsbloodprogenitorsintheposteriorlobesofthedrosophilalarvallymphgland
_version_	1718375683480092672

Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.

Ejemplares similares