R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.

The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-catenin signaling, however, the molecular mechanism of RSPO action is not yet fully understood. We performed an unbiased siRN...

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Main Authors: Heinz Ruffner, Joëlle Sprunger, Olga Charlat, Juliet Leighton-Davies, Bianka Grosshans, Adrian Salathe, Svenja Zietzling, Valérie Beck, Maxime Therier, Andrea Isken, Yang Xie, Yue Zhang, Huaixiang Hao, Xiaoying Shi, Dong Liu, Qinhui Song, Ieuan Clay, Gabriele Hintzen, Jan Tchorz, Laure C Bouchez, Gregory Michaud, Peter Finan, Vic E Myer, Tewis Bouwmeester, Jeff Porter, Marc Hild, Fred Bassilana, Christian N Parker, Feng Cong
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/bd2794bcdd5c40a0903a9b2a0d7c9a22
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https://doaj.org/article/bd2794bcdd5c40a0903a9b2a0d7c9a22

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