HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses

HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses

ABSTRACT The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this site and inhibit its activity. Herpes simplex virus (HSV) encodes two proteins with potential RNase H-like folds, the infected cell protein 8 (ICP8) DNA...

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Autores principales: Zhipeng Yan, Kevin F. Bryant, Sean M. Gregory, Magdalena Angelova, David H. Dreyfus, Xue Zhi Zhao, Donald M. Coen, Terrence R. Burke, David M. Knipe
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/bd2aa3329d484028a74c9f55ebba28f2
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