Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice

Ammara Arif, Attya Bhatti, Peter John Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, PakistanCorrespondence: Attya BhattiAtta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, H-12, Islamabad, PakistanTe...

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Autores principales:	Arif A, Bhatti A, John P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	rheumatoid arthritis nanotherapy selenium deficiency plant seed extract balb/c mice Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bd2acead48a14de8a5ad49bc3fffe38e
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spelling	oai:doaj.org-article:bd2acead48a14de8a5ad49bc3fffe38e2021-12-02T08:18:06ZTherapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice1178-2013https://doaj.org/article/bd2acead48a14de8a5ad49bc3fffe38e2019-10-01T00:00:00Zhttps://www.dovepress.com/therapeutic-potential-of-foeniculum-vulgare-mill-derived-selenium-nano-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ammara Arif, Attya Bhatti, Peter John Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, PakistanCorrespondence: Attya BhattiAtta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, H-12, Islamabad, PakistanTel +92 51 90856128Fax +92 51 90856102Email attyabhatti@gmail.comPurpose: Rheumatoid arthritis is an inflammatory autoimmune multifactorial disorder that primarily affects the joints. Currently available treatment options, although effective, still present some side effects. This study proposes an alternative treatment option for rheumatoid arthritis through elucidation of therapeutic potential of Foeniculum vulgare Mill.-derived selenium nanoparticles in arthritic Balb/c mice.Methods: Synthesis and characterization of selenium nanoparticles were followed by their toxicity analysis on healthy mice. Subsequently, anti-arthritic efficacy of two doses (5 mg/kg and 10 mg/kg) of synthesized selenium nanoparticles was checked on arthritic mice using multiple parameters.Results: Selenium nanoparticles in 10 mg/kg dose turned out to be more effective in treatment of rheumatoid arthritis as evident by significant reduction in paw volume and normal clinical chemistry parameters of treated arthritic mice. This dose also showed significant antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.Conclusion: Foeniculum vulgare Mill.-derived selenium nanoparticles retain significant anti-arthritic and antioxidant potential and consequently can further be explored as an alternative treatment option for rheumatoid arthritis.Keywords: rheumatoid arthritis, nanotherapy, selenium deficiency, plant seed extract, Balb/c miceArif ABhatti AJohn PDove Medical Pressarticlerheumatoid arthritisnanotherapyselenium deficiencyplant seed extractbalb/c miceMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8561-8572 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis nanotherapy selenium deficiency plant seed extract balb/c mice Medicine (General) R5-920
spellingShingle	rheumatoid arthritis nanotherapy selenium deficiency plant seed extract balb/c mice Medicine (General) R5-920 Arif A Bhatti A John P Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice
description	Ammara Arif, Attya Bhatti, Peter John Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, PakistanCorrespondence: Attya BhattiAtta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, H-12, Islamabad, PakistanTel +92 51 90856128Fax +92 51 90856102Email attyabhatti@gmail.comPurpose: Rheumatoid arthritis is an inflammatory autoimmune multifactorial disorder that primarily affects the joints. Currently available treatment options, although effective, still present some side effects. This study proposes an alternative treatment option for rheumatoid arthritis through elucidation of therapeutic potential of Foeniculum vulgare Mill.-derived selenium nanoparticles in arthritic Balb/c mice.Methods: Synthesis and characterization of selenium nanoparticles were followed by their toxicity analysis on healthy mice. Subsequently, anti-arthritic efficacy of two doses (5 mg/kg and 10 mg/kg) of synthesized selenium nanoparticles was checked on arthritic mice using multiple parameters.Results: Selenium nanoparticles in 10 mg/kg dose turned out to be more effective in treatment of rheumatoid arthritis as evident by significant reduction in paw volume and normal clinical chemistry parameters of treated arthritic mice. This dose also showed significant antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.Conclusion: Foeniculum vulgare Mill.-derived selenium nanoparticles retain significant anti-arthritic and antioxidant potential and consequently can further be explored as an alternative treatment option for rheumatoid arthritis.Keywords: rheumatoid arthritis, nanotherapy, selenium deficiency, plant seed extract, Balb/c mice
format	article
author	Arif A Bhatti A John P
author_facet	Arif A Bhatti A John P
author_sort	Arif A
title	Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice
title_short	Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice
title_full	Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice
title_fullStr	Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice
title_full_unstemmed	Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice
title_sort	therapeutic potential of foeniculum vulgare mill. derived selenium nanoparticles in arthritic balb/c mice
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/bd2acead48a14de8a5ad49bc3fffe38e
work_keys_str_mv	AT arifa therapeuticpotentialoffoeniculumvulgaremillderivedseleniumnanoparticlesinarthriticbalbcmice AT bhattia therapeuticpotentialoffoeniculumvulgaremillderivedseleniumnanoparticlesinarthriticbalbcmice AT johnp therapeuticpotentialoffoeniculumvulgaremillderivedseleniumnanoparticlesinarthriticbalbcmice
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Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice

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