Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis

Abstract Toxoplasma gondii is an opportunistic protozoan pathogen with a wide geographic distribution. The chronic phase of toxoplasmosis is often asymptomatic in humans and is characterized by tissue cysts throughout the central nervous system and muscle cells. T. gondii and other pathogens with tr...

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Autores principales:	Mariana Acquarone, A. Poleto, A. F. Perozzo, P. F. R. Gonçalves, R. Panizzutti, J. R. L. Menezes, G. A. Neves, Helene Santos Barbosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd2cc3c35f5f4550b7f9169b029849f7
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spelling	oai:doaj.org-article:bd2cc3c35f5f4550b7f9169b029849f72021-12-02T16:15:06ZSocial preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis10.1038/s41598-021-93504-12045-2322https://doaj.org/article/bd2cc3c35f5f4550b7f9169b029849f72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93504-1https://doaj.org/toc/2045-2322Abstract Toxoplasma gondii is an opportunistic protozoan pathogen with a wide geographic distribution. The chronic phase of toxoplasmosis is often asymptomatic in humans and is characterized by tissue cysts throughout the central nervous system and muscle cells. T. gondii and other pathogens with tropism for the central nervous system are considered risk factors in the etiology of several neuropsychiatric disorders, such as schizophrenia and bipolar disorder, besides neurological diseases. Currently, it is known that cerebral toxoplasmosis increases dopamine levels in the brain and it is related to behavioral changes in animals and humans. Here we evaluate whether chronic T. gondii infection, using the cystogenic ME-49 strain, could induce behavioral alterations associated with neuropsychiatric disorders and glutamatergic neurotransmission dysfunction. We observed that the startle amplitude is reduced in the infected animals as well as glutamate and D-serine levels in prefrontal cortical and hippocampal tissue homogenates. Moreover, we did not detect alterations in social preference and spontaneous alternation despite severe motor impairment. Thus, we conclude that behavioral and cognitive aspects are maintained even though severe neural damage is observed by chronic infection of C57Bl/6 mice with the ME-49 strain.Mariana AcquaroneA. PoletoA. F. PerozzoP. F. R. GonçalvesR. PanizzuttiJ. R. L. MenezesG. A. NevesHelene Santos BarbosaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariana Acquarone A. Poleto A. F. Perozzo P. F. R. Gonçalves R. Panizzutti J. R. L. Menezes G. A. Neves Helene Santos Barbosa Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis
description	Abstract Toxoplasma gondii is an opportunistic protozoan pathogen with a wide geographic distribution. The chronic phase of toxoplasmosis is often asymptomatic in humans and is characterized by tissue cysts throughout the central nervous system and muscle cells. T. gondii and other pathogens with tropism for the central nervous system are considered risk factors in the etiology of several neuropsychiatric disorders, such as schizophrenia and bipolar disorder, besides neurological diseases. Currently, it is known that cerebral toxoplasmosis increases dopamine levels in the brain and it is related to behavioral changes in animals and humans. Here we evaluate whether chronic T. gondii infection, using the cystogenic ME-49 strain, could induce behavioral alterations associated with neuropsychiatric disorders and glutamatergic neurotransmission dysfunction. We observed that the startle amplitude is reduced in the infected animals as well as glutamate and D-serine levels in prefrontal cortical and hippocampal tissue homogenates. Moreover, we did not detect alterations in social preference and spontaneous alternation despite severe motor impairment. Thus, we conclude that behavioral and cognitive aspects are maintained even though severe neural damage is observed by chronic infection of C57Bl/6 mice with the ME-49 strain.
format	article
author	Mariana Acquarone A. Poleto A. F. Perozzo P. F. R. Gonçalves R. Panizzutti J. R. L. Menezes G. A. Neves Helene Santos Barbosa
author_facet	Mariana Acquarone A. Poleto A. F. Perozzo P. F. R. Gonçalves R. Panizzutti J. R. L. Menezes G. A. Neves Helene Santos Barbosa
author_sort	Mariana Acquarone
title	Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis
title_short	Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis
title_full	Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis
title_fullStr	Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis
title_full_unstemmed	Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis
title_sort	social preference is maintained in mice with impaired startle reflex and glutamate/d-serine imbalance induced by chronic cerebral toxoplasmosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd2cc3c35f5f4550b7f9169b029849f7
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Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis

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