Complete mitochondrial genomes reveal neolithic expansion into Europe.

The Neolithic transition from hunting and gathering to farming and cattle breeding marks one of the most drastic cultural changes in European prehistory. Short stretches of ancient mitochondrial DNA (mtDNA) from skeletons of pre-Neolithic hunter-gatherers as well as early Neolithic farmers support t...

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Autores principales:	Qiaomei Fu, Pavao Rudan, Svante Pääbo, Johannes Krause
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd2f68d241f64196b545b5ae5e76921c
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spelling	oai:doaj.org-article:bd2f68d241f64196b545b5ae5e76921c2021-11-18T07:25:21ZComplete mitochondrial genomes reveal neolithic expansion into Europe.1932-620310.1371/journal.pone.0032473https://doaj.org/article/bd2f68d241f64196b545b5ae5e76921c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427842/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The Neolithic transition from hunting and gathering to farming and cattle breeding marks one of the most drastic cultural changes in European prehistory. Short stretches of ancient mitochondrial DNA (mtDNA) from skeletons of pre-Neolithic hunter-gatherers as well as early Neolithic farmers support the demic diffusion model where a migration of early farmers from the Near East and a replacement of pre-Neolithic hunter-gatherers are largely responsible for cultural innovation and changes in subsistence strategies during the Neolithic revolution in Europe. In order to test if a signal of population expansion is still present in modern European mitochondrial DNA, we analyzed a comprehensive dataset of 1,151 complete mtDNAs from present-day Europeans. Relying upon ancient DNA data from previous investigations, we identified mtDNA haplogroups that are typical for early farmers and hunter-gatherers, namely H and U respectively. Bayesian skyline coalescence estimates were then used on subsets of complete mtDNAs from modern populations to look for signals of past population expansions. Our analyses revealed a population expansion between 15,000 and 10,000 years before present (YBP) in mtDNAs typical for hunters and gatherers, with a decline between 10,000 and 5,000 YBP. These corresponded to an analogous population increase approximately 9,000 YBP for mtDNAs typical of early farmers. The observed changes over time suggest that the spread of agriculture in Europe involved the expansion of farming populations into Europe followed by the eventual assimilation of resident hunter-gatherers. Our data show that contemporary mtDNA datasets can be used to study ancient population history if only limited ancient genetic data is available.Qiaomei FuPavao RudanSvante PääboJohannes KrausePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32473 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiaomei Fu Pavao Rudan Svante Pääbo Johannes Krause Complete mitochondrial genomes reveal neolithic expansion into Europe.
description	The Neolithic transition from hunting and gathering to farming and cattle breeding marks one of the most drastic cultural changes in European prehistory. Short stretches of ancient mitochondrial DNA (mtDNA) from skeletons of pre-Neolithic hunter-gatherers as well as early Neolithic farmers support the demic diffusion model where a migration of early farmers from the Near East and a replacement of pre-Neolithic hunter-gatherers are largely responsible for cultural innovation and changes in subsistence strategies during the Neolithic revolution in Europe. In order to test if a signal of population expansion is still present in modern European mitochondrial DNA, we analyzed a comprehensive dataset of 1,151 complete mtDNAs from present-day Europeans. Relying upon ancient DNA data from previous investigations, we identified mtDNA haplogroups that are typical for early farmers and hunter-gatherers, namely H and U respectively. Bayesian skyline coalescence estimates were then used on subsets of complete mtDNAs from modern populations to look for signals of past population expansions. Our analyses revealed a population expansion between 15,000 and 10,000 years before present (YBP) in mtDNAs typical for hunters and gatherers, with a decline between 10,000 and 5,000 YBP. These corresponded to an analogous population increase approximately 9,000 YBP for mtDNAs typical of early farmers. The observed changes over time suggest that the spread of agriculture in Europe involved the expansion of farming populations into Europe followed by the eventual assimilation of resident hunter-gatherers. Our data show that contemporary mtDNA datasets can be used to study ancient population history if only limited ancient genetic data is available.
format	article
author	Qiaomei Fu Pavao Rudan Svante Pääbo Johannes Krause
author_facet	Qiaomei Fu Pavao Rudan Svante Pääbo Johannes Krause
author_sort	Qiaomei Fu
title	Complete mitochondrial genomes reveal neolithic expansion into Europe.
title_short	Complete mitochondrial genomes reveal neolithic expansion into Europe.
title_full	Complete mitochondrial genomes reveal neolithic expansion into Europe.
title_fullStr	Complete mitochondrial genomes reveal neolithic expansion into Europe.
title_full_unstemmed	Complete mitochondrial genomes reveal neolithic expansion into Europe.
title_sort	complete mitochondrial genomes reveal neolithic expansion into europe.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bd2f68d241f64196b545b5ae5e76921c
work_keys_str_mv	AT qiaomeifu completemitochondrialgenomesrevealneolithicexpansionintoeurope AT pavaorudan completemitochondrialgenomesrevealneolithicexpansionintoeurope AT svantepaabo completemitochondrialgenomesrevealneolithicexpansionintoeurope AT johanneskrause completemitochondrialgenomesrevealneolithicexpansionintoeurope
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Complete mitochondrial genomes reveal neolithic expansion into Europe.

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