Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)

Premna serratifolia known as bebuas has long been used by Malay comunity for both food and traditional medicine. The most notable advantage of this plant is to heal woman after childbirth and to raise the notion that contains anti-inflammatory bioactive compounds. In this study, the hexane extract o...

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Autores principales:	Muhaimin Muhaimin, Muhammad Irhash Shalihin, Madyawati Latief
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2021
Materias:	premna serratifolia anti-inflammatory indole alkaloid bufotenine Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bd32470f53f64935acdebe54fa0410f6
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spelling	oai:doaj.org-article:bd32470f53f64935acdebe54fa0410f62021-11-24T11:59:58ZAnti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)2302-46902541-0733https://doaj.org/article/bd32470f53f64935acdebe54fa0410f62021-07-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/584/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2541-0733Premna serratifolia known as bebuas has long been used by Malay comunity for both food and traditional medicine. The most notable advantage of this plant is to heal woman after childbirth and to raise the notion that contains anti-inflammatory bioactive compounds. In this study, the hexane extract of bebuas was only contained steroids. Meanwhile the ethanol extract contained various secondary metabolites such as phenolics, alkaloids, flavonoids, steroids and saponins. The ethanol extract was further separated since the targeted compound isolate was an alkaloid. The isolate obtained was a yellow crystal which transformed to yellow oil after being exposed to air. The anti-inflammatory evaluation of the compound gave a result with a strong activity with ED50 = 4.06 mg/KgBW. Characterization by UV-Vis and FT-IR showed that the isolate’s spectra pattern had similarities with bufotenine. It revealed that the isolate shared the same basic skeleton with the bufotenine, especially the indole skeleton. Furthermore, it also shared the same physical form with bufotenine. These evidences strengthened the assumption that the isolate was an indole alkaloid.Muhaimin MuhaiminMuhammad Irhash ShalihinMadyawati LatiefUniversity of Brawijayaarticlepremna serratifoliaanti-inflammatoryindolealkaloidbufotenineChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 10, Iss 2, Pp 84-103 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	premna serratifolia anti-inflammatory indole alkaloid bufotenine Chemistry QD1-999
spellingShingle	premna serratifolia anti-inflammatory indole alkaloid bufotenine Chemistry QD1-999 Muhaimin Muhaimin Muhammad Irhash Shalihin Madyawati Latief Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)
description	Premna serratifolia known as bebuas has long been used by Malay comunity for both food and traditional medicine. The most notable advantage of this plant is to heal woman after childbirth and to raise the notion that contains anti-inflammatory bioactive compounds. In this study, the hexane extract of bebuas was only contained steroids. Meanwhile the ethanol extract contained various secondary metabolites such as phenolics, alkaloids, flavonoids, steroids and saponins. The ethanol extract was further separated since the targeted compound isolate was an alkaloid. The isolate obtained was a yellow crystal which transformed to yellow oil after being exposed to air. The anti-inflammatory evaluation of the compound gave a result with a strong activity with ED50 = 4.06 mg/KgBW. Characterization by UV-Vis and FT-IR showed that the isolate’s spectra pattern had similarities with bufotenine. It revealed that the isolate shared the same basic skeleton with the bufotenine, especially the indole skeleton. Furthermore, it also shared the same physical form with bufotenine. These evidences strengthened the assumption that the isolate was an indole alkaloid.
format	article
author	Muhaimin Muhaimin Muhammad Irhash Shalihin Madyawati Latief
author_facet	Muhaimin Muhaimin Muhammad Irhash Shalihin Madyawati Latief
author_sort	Muhaimin Muhaimin
title	Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)
title_short	Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)
title_full	Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)
title_fullStr	Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)
title_full_unstemmed	Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)
title_sort	anti-inflammatory activity of an indole alkaloid isolated from bebuas (premna serratifolia)
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/bd32470f53f64935acdebe54fa0410f6
work_keys_str_mv	AT muhaiminmuhaimin antiinflammatoryactivityofanindolealkaloidisolatedfrombebuaspremnaserratifolia AT muhammadirhashshalihin antiinflammatoryactivityofanindolealkaloidisolatedfrombebuaspremnaserratifolia AT madyawatilatief antiinflammatoryactivityofanindolealkaloidisolatedfrombebuaspremnaserratifolia
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Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)

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