Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic differentiation, and tendon regeneration in a rat...

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Autores principales:	Yu Wang, Shanshan Jin, Dan Luo, Danqing He, Chunyan Shi, Lisha Zhu, Bo Guan, Zixin Li, Ting Zhang, Yanheng Zhou, Cun-Yu Wang, Yan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd4583826f0e4afa87e882618523d270
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spelling	oai:doaj.org-article:bd4583826f0e4afa87e882618523d2702021-12-02T13:14:53ZFunctional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin10.1038/s41467-021-21545-12041-1723https://doaj.org/article/bd4583826f0e4afa87e882618523d2702021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21545-1https://doaj.org/toc/2041-1723The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic differentiation, and tendon regeneration in a rat full-cut Achilles tendon defect model.Yu WangShanshan JinDan LuoDanqing HeChunyan ShiLisha ZhuBo GuanZixin LiTing ZhangYanheng ZhouCun-Yu WangYan LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Wang Shanshan Jin Dan Luo Danqing He Chunyan Shi Lisha Zhu Bo Guan Zixin Li Ting Zhang Yanheng Zhou Cun-Yu Wang Yan Liu Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
description	The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic differentiation, and tendon regeneration in a rat full-cut Achilles tendon defect model.
format	article
author	Yu Wang Shanshan Jin Dan Luo Danqing He Chunyan Shi Lisha Zhu Bo Guan Zixin Li Ting Zhang Yanheng Zhou Cun-Yu Wang Yan Liu
author_facet	Yu Wang Shanshan Jin Dan Luo Danqing He Chunyan Shi Lisha Zhu Bo Guan Zixin Li Ting Zhang Yanheng Zhou Cun-Yu Wang Yan Liu
author_sort	Yu Wang
title	Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
title_short	Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
title_full	Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
title_fullStr	Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
title_full_unstemmed	Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
title_sort	functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd4583826f0e4afa87e882618523d270
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Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

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