The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus
BACKGROUND: Male hypogonadism is a frequent complication of diabetes mellitus (DM) type 2; therefore, a study of its clinical and epidemiological characteristics is of interest. AIMS: Assessment of clinical and epidemiological characteristics of hypogonadism in men with diabetes mellitus type 2. M...
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Endocrinology Research Centre
2019
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oai:doaj.org-article:bd4dab4316e74a8a829b588641316a292021-11-14T09:00:22ZThe clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus2072-03512072-037810.14341/DM10211https://doaj.org/article/bd4dab4316e74a8a829b588641316a292019-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10211https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: Male hypogonadism is a frequent complication of diabetes mellitus (DM) type 2; therefore, a study of its clinical and epidemiological characteristics is of interest. AIMS: Assessment of clinical and epidemiological characteristics of hypogonadism in men with diabetes mellitus type 2. METHODS: A full-design, cross-sectional, screening, multicenter, non-interventional study included men with diabetes mellitus type 2. The study was conducted from November 2017 to January 2019.Medical history assessment, sexological testing, estimation of luteinizing hormone (LH), sex hormone-binding globulin; total testosterone and glycated hemoglobin were performed. Free testosterone was calculated by the Vermeullen method. Comparison of groups was carried out using Yates’s corrected version of chi-squared test, Mann-Whitney U-test, and Spearman’s rank correlation method was also used. Differences were considered statistically significant with p <0,05. RESULTS: The age of 554 men included in the study was 55 [50; 58] years, total testosterone level was 12,5 [9,1; 16,4] nmol/L; free testosterone was 0,266 [0,205; 0,333] nmol/L; HbA1c 7,2 [6,2; 8,9] %. Hypogonadism syndrome was detected in 181 men (32,7%). Total testosterone level in these patients was 7,8 [6,5; 9,4] nmol/L, and free testosterone level was 0,182 [0,152; 0,217] nmol/L. In patients without hypogonadism, these parameters were 14,7 [12,4; 18,0] nmol/L and 0,308 [0,265; 0,362] nmol/L, respectively. In most cases, patients with hypogonadism had normal, but lower LH levels of 3,3 [2,2; 4,9] U/L compared with patients without hypogonadism 3,8 [2,7; 4,9], p = 0,022. Most often, normogonadotropic hypogonadism was detected (89,5%). Statistically significant negative correlations were found between total testosterone levels and body mass index (r = -0,24; p <0,001), and waist circumference (r = -0,21; p<0,001). The prevalence of decreased libido in patients with hypogonadism (66,8%) is statistically significantly higher than that in men without hypogonadism (56,3%, p = 0,022). CONCLUSIONS: The prevalence of hypogonadism syndrome in men with diabetes mellitus type 2 is 32,7%. This type of hypogonadism is characterized by normal LH values.Galina A. Mel'nichenkoMarina V. ShestakovaRoman V. RozhivanovEndocrinology Research Centrearticlehypogonadismmentestosterone deficiencytestosteronediabetes mellitusNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 6, Pp 536-541 (2019) |
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EN RU |
| topic |
hypogonadism men testosterone deficiency testosterone diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
hypogonadism men testosterone deficiency testosterone diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 Galina A. Mel'nichenko Marina V. Shestakova Roman V. Rozhivanov The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| description |
BACKGROUND: Male hypogonadism is a frequent complication of diabetes mellitus (DM) type 2; therefore, a study of its clinical and epidemiological characteristics is of interest.
AIMS: Assessment of clinical and epidemiological characteristics of hypogonadism in men with diabetes mellitus type 2.
METHODS: A full-design, cross-sectional, screening, multicenter, non-interventional study included men with diabetes mellitus type 2. The study was conducted from November 2017 to January 2019.Medical history assessment, sexological testing, estimation of luteinizing hormone (LH), sex hormone-binding globulin; total testosterone and glycated hemoglobin were performed. Free testosterone was calculated by the Vermeullen method. Comparison of groups was carried out using Yates’s corrected version of chi-squared test, Mann-Whitney U-test, and Spearman’s rank correlation method was also used. Differences were considered statistically significant with p <0,05.
RESULTS: The age of 554 men included in the study was 55 [50; 58] years, total testosterone level was 12,5 [9,1; 16,4] nmol/L; free testosterone was 0,266 [0,205; 0,333] nmol/L; HbA1c 7,2 [6,2; 8,9] %. Hypogonadism syndrome was detected in 181 men (32,7%). Total testosterone level in these patients was 7,8 [6,5; 9,4] nmol/L, and free testosterone level was 0,182 [0,152; 0,217] nmol/L. In patients without hypogonadism, these parameters were 14,7 [12,4; 18,0] nmol/L and 0,308 [0,265; 0,362] nmol/L, respectively. In most cases, patients with hypogonadism had normal, but lower LH levels of 3,3 [2,2; 4,9] U/L compared with patients without hypogonadism 3,8 [2,7; 4,9], p = 0,022. Most often, normogonadotropic hypogonadism was detected (89,5%). Statistically significant negative correlations were found between total testosterone levels and body mass index (r = -0,24; p <0,001), and waist circumference (r = -0,21; p<0,001). The prevalence of decreased libido in patients with hypogonadism (66,8%) is statistically significantly higher than that in men without hypogonadism (56,3%, p = 0,022).
CONCLUSIONS: The prevalence of hypogonadism syndrome in men with diabetes mellitus type 2 is 32,7%. This type of hypogonadism is characterized by normal LH values. |
| format |
article |
| author |
Galina A. Mel'nichenko Marina V. Shestakova Roman V. Rozhivanov |
| author_facet |
Galina A. Mel'nichenko Marina V. Shestakova Roman V. Rozhivanov |
| author_sort |
Galina A. Mel'nichenko |
| title |
The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| title_short |
The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| title_full |
The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| title_fullStr |
The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| title_full_unstemmed |
The clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| title_sort |
clinical and epidemiological characteristics of hypogonadism in men with type 2 diabetes mellitus |
| publisher |
Endocrinology Research Centre |
| publishDate |
2019 |
| url |
https://doaj.org/article/bd4dab4316e74a8a829b588641316a29 |
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