DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

T cells derived from stem cells can be harnessed for regenerative medicine and cancer immunotherapy, but current technologies limit production and translation. Here, the authors present a serum-free, stromal-cell free DLL4-coated microbead method for the scalable production of T-lineage cells from m...

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Autores principales:	Ashton C. Trotman-Grant, Mahmood Mohtashami, Joshua De Sousa Casal, Elisa C. Martinez, Dylan Lee, Sintia Teichman, Patrick M. Brauer, Jianxun Han, Michele K. Anderson, Juan Carlos Zúñiga-Pflücker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd5e8ce1d6374c98b723e98229e9b961
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spelling	oai:doaj.org-article:bd5e8ce1d6374c98b723e98229e9b9612021-12-02T17:08:39ZDL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system10.1038/s41467-021-25245-82041-1723https://doaj.org/article/bd5e8ce1d6374c98b723e98229e9b9612021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25245-8https://doaj.org/toc/2041-1723T cells derived from stem cells can be harnessed for regenerative medicine and cancer immunotherapy, but current technologies limit production and translation. Here, the authors present a serum-free, stromal-cell free DLL4-coated microbead method for the scalable production of T-lineage cells from multiple sources of stem cells.Ashton C. Trotman-GrantMahmood MohtashamiJoshua De Sousa CasalElisa C. MartinezDylan LeeSintia TeichmanPatrick M. BrauerJianxun HanMichele K. AndersonJuan Carlos Zúñiga-PflückerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashton C. Trotman-Grant Mahmood Mohtashami Joshua De Sousa Casal Elisa C. Martinez Dylan Lee Sintia Teichman Patrick M. Brauer Jianxun Han Michele K. Anderson Juan Carlos Zúñiga-Pflücker DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
description	T cells derived from stem cells can be harnessed for regenerative medicine and cancer immunotherapy, but current technologies limit production and translation. Here, the authors present a serum-free, stromal-cell free DLL4-coated microbead method for the scalable production of T-lineage cells from multiple sources of stem cells.
format	article
author	Ashton C. Trotman-Grant Mahmood Mohtashami Joshua De Sousa Casal Elisa C. Martinez Dylan Lee Sintia Teichman Patrick M. Brauer Jianxun Han Michele K. Anderson Juan Carlos Zúñiga-Pflücker
author_facet	Ashton C. Trotman-Grant Mahmood Mohtashami Joshua De Sousa Casal Elisa C. Martinez Dylan Lee Sintia Teichman Patrick M. Brauer Jianxun Han Michele K. Anderson Juan Carlos Zúñiga-Pflücker
author_sort	Ashton C. Trotman-Grant
title	DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
title_short	DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
title_full	DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
title_fullStr	DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
title_full_unstemmed	DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
title_sort	dl4-μbeads induce t cell lineage differentiation from stem cells in a stromal cell-free system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd5e8ce1d6374c98b723e98229e9b961
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DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

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