Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI

Abstract We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The imag...

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Autores principales:	Bo-Rong Lin, Chien-Hsu Chen, Srinivasu Kunuku, Tzung-Yuang Chen, Tung-Yuan Hsiao, Huan Niu, Chien-Ping Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd5f4628deb04a7e866a6ca84c03e14c
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spelling	oai:doaj.org-article:bd5f4628deb04a7e866a6ca84c03e14c2021-12-02T15:05:02ZFe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI10.1038/s41598-018-25380-12045-2322https://doaj.org/article/bd5f4628deb04a7e866a6ca84c03e14c2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25380-1https://doaj.org/toc/2045-2322Abstract We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The image enhancement was shown clearly through T2 weighted images. The concentration dependence of the T2 relaxation time gives a relaxivity value that is about seven times that of the regular non-magnetic nanodiamonds. Cell viability study has also been performed. It was shown that they were nearly free from cytotoxicity independent of the particle concentration used. The imaging capability demonstrated here adds a new dimension to the medical application of nanodiamonds. In the future one will be able to combine this capability of magnetic nanodiamonds with other functions through surface modifications to perform drug delivery, targeted therapy, localized thermal treatment and diagnostic imaging at the same time.Bo-Rong LinChien-Hsu ChenSrinivasu KunukuTzung-Yuang ChenTung-Yuan HsiaoHuan NiuChien-Ping LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo-Rong Lin Chien-Hsu Chen Srinivasu Kunuku Tzung-Yuang Chen Tung-Yuan Hsiao Huan Niu Chien-Ping Lee Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
description	Abstract We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The image enhancement was shown clearly through T2 weighted images. The concentration dependence of the T2 relaxation time gives a relaxivity value that is about seven times that of the regular non-magnetic nanodiamonds. Cell viability study has also been performed. It was shown that they were nearly free from cytotoxicity independent of the particle concentration used. The imaging capability demonstrated here adds a new dimension to the medical application of nanodiamonds. In the future one will be able to combine this capability of magnetic nanodiamonds with other functions through surface modifications to perform drug delivery, targeted therapy, localized thermal treatment and diagnostic imaging at the same time.
format	article
author	Bo-Rong Lin Chien-Hsu Chen Srinivasu Kunuku Tzung-Yuang Chen Tung-Yuan Hsiao Huan Niu Chien-Ping Lee
author_facet	Bo-Rong Lin Chien-Hsu Chen Srinivasu Kunuku Tzung-Yuang Chen Tung-Yuan Hsiao Huan Niu Chien-Ping Lee
author_sort	Bo-Rong Lin
title	Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
title_short	Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
title_full	Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
title_fullStr	Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
title_full_unstemmed	Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
title_sort	fe doped magnetic nanodiamonds made by ion implantation as contrast agent for mri
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bd5f4628deb04a7e866a6ca84c03e14c
work_keys_str_mv	AT boronglin fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri AT chienhsuchen fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri AT srinivasukunuku fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri AT tzungyuangchen fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri AT tungyuanhsiao fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri AT huanniu fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri AT chienpinglee fedopedmagneticnanodiamondsmadebyionimplantationascontrastagentformri
_version_	1718388979636633600

Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI

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