Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Summary: Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment...

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Autores principales:	Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	malaria liver-stage immunity CD8 T cells Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bd5f91fa19ff4eed920a3ac786cb0f9f
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spelling	oai:doaj.org-article:bd5f91fa19ff4eed920a3ac786cb0f9f2021-11-04T04:29:51ZExpeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria2211-124710.1016/j.celrep.2021.109956https://doaj.org/article/bd5f91fa19ff4eed920a3ac786cb0f9f2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014339https://doaj.org/toc/2211-1247Summary: Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment coincides with rapid transcriptional upregulation of inflammatory genes in Plasmodium-infected livers. Recruitment requires CD8 T cell-intrinsic LFA-1 expression and the presence of liver phagocytes. Rapid Tem liver infiltration is distinct from recruitment to other non-lymphoid tissues in that it occurs both in the absence of liver tissue resident memory “sensing-and-alarm” function and ∼42 hours earlier than in lung infection by influenza virus. These data demonstrate relevance for Tem in protection against malaria and provide generalizable mechanistic insights germane to control of liver infections.Mitchell N. LefebvreFionna A. SuretteScott M. AnthonyRahul VijayIsaac J. JensenLecia L. PeweLisa S. HancoxNatalija Van Braeckel-BudimirStephanie van de WallStina L. UrbanMadison R. MixSamarchith P. KurupVladimir P. BadovinacNoah S. ButlerJohn T. HartyElsevierarticlemalarialiver-stage immunityCD8 T cellsBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109956- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malaria liver-stage immunity CD8 T cells Biology (General) QH301-705.5
spellingShingle	malaria liver-stage immunity CD8 T cells Biology (General) QH301-705.5 Mitchell N. Lefebvre Fionna A. Surette Scott M. Anthony Rahul Vijay Isaac J. Jensen Lecia L. Pewe Lisa S. Hancox Natalija Van Braeckel-Budimir Stephanie van de Wall Stina L. Urban Madison R. Mix Samarchith P. Kurup Vladimir P. Badovinac Noah S. Butler John T. Harty Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
description	Summary: Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment coincides with rapid transcriptional upregulation of inflammatory genes in Plasmodium-infected livers. Recruitment requires CD8 T cell-intrinsic LFA-1 expression and the presence of liver phagocytes. Rapid Tem liver infiltration is distinct from recruitment to other non-lymphoid tissues in that it occurs both in the absence of liver tissue resident memory “sensing-and-alarm” function and ∼42 hours earlier than in lung infection by influenza virus. These data demonstrate relevance for Tem in protection against malaria and provide generalizable mechanistic insights germane to control of liver infections.
format	article
author	Mitchell N. Lefebvre Fionna A. Surette Scott M. Anthony Rahul Vijay Isaac J. Jensen Lecia L. Pewe Lisa S. Hancox Natalija Van Braeckel-Budimir Stephanie van de Wall Stina L. Urban Madison R. Mix Samarchith P. Kurup Vladimir P. Badovinac Noah S. Butler John T. Harty
author_facet	Mitchell N. Lefebvre Fionna A. Surette Scott M. Anthony Rahul Vijay Isaac J. Jensen Lecia L. Pewe Lisa S. Hancox Natalija Van Braeckel-Budimir Stephanie van de Wall Stina L. Urban Madison R. Mix Samarchith P. Kurup Vladimir P. Badovinac Noah S. Butler John T. Harty
author_sort	Mitchell N. Lefebvre
title	Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
title_short	Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
title_full	Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
title_fullStr	Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
title_full_unstemmed	Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
title_sort	expeditious recruitment of circulating memory cd8 t cells to the liver facilitates control of malaria
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bd5f91fa19ff4eed920a3ac786cb0f9f
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Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

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