A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4

The centrosome is a large intracellular structure that serves as the microtubule-organising center, but how it is accurately assembled is not known. Here the authors generate a ‘domain-level’ centrosome interactome and show that Plk4 positions the essential centriole component Asterless by phosphory...

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Autores principales:	Brian J. Galletta, Carey J. Fagerstrom, Todd A. Schoborg, Tiffany A. McLamarrah, John M. Ryniawec, Daniel W. Buster, Kevin C. Slep, Gregory C. Rogers, Nasser M. Rusan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd602ba043d3456eb55d85545a7af134
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spelling	oai:doaj.org-article:bd602ba043d3456eb55d85545a7af1342021-12-02T14:39:33ZA centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk410.1038/ncomms124762041-1723https://doaj.org/article/bd602ba043d3456eb55d85545a7af1342016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12476https://doaj.org/toc/2041-1723The centrosome is a large intracellular structure that serves as the microtubule-organising center, but how it is accurately assembled is not known. Here the authors generate a ‘domain-level’ centrosome interactome and show that Plk4 positions the essential centriole component Asterless by phosphorylating Cep135.Brian J. GallettaCarey J. FagerstromTodd A. SchoborgTiffany A. McLamarrahJohn M. RyniawecDaniel W. BusterKevin C. SlepGregory C. RogersNasser M. RusanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian J. Galletta Carey J. Fagerstrom Todd A. Schoborg Tiffany A. McLamarrah John M. Ryniawec Daniel W. Buster Kevin C. Slep Gregory C. Rogers Nasser M. Rusan A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
description	The centrosome is a large intracellular structure that serves as the microtubule-organising center, but how it is accurately assembled is not known. Here the authors generate a ‘domain-level’ centrosome interactome and show that Plk4 positions the essential centriole component Asterless by phosphorylating Cep135.
format	article
author	Brian J. Galletta Carey J. Fagerstrom Todd A. Schoborg Tiffany A. McLamarrah John M. Ryniawec Daniel W. Buster Kevin C. Slep Gregory C. Rogers Nasser M. Rusan
author_facet	Brian J. Galletta Carey J. Fagerstrom Todd A. Schoborg Tiffany A. McLamarrah John M. Ryniawec Daniel W. Buster Kevin C. Slep Gregory C. Rogers Nasser M. Rusan
author_sort	Brian J. Galletta
title	A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
title_short	A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
title_full	A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
title_fullStr	A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
title_full_unstemmed	A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4
title_sort	centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for plk4
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bd602ba043d3456eb55d85545a7af134
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A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4

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