Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III

The formation of solid solutions can result in changes of relative stabilities of crystal polymorphs. Here, the elusive form III of benzamide is stabilized through solid solution formation with nicotinamide. It is shown, experimentally and computationally, how such thermodynamic switching allows for...

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Autores principales:	Weronika Kras, Andrea Carletta, Riccardo Montis, Rachel A. Sullivan, Aurora J. Cruz-Cabeza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bd624f36d9774719a22987f0daae1e82
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spelling	oai:doaj.org-article:bd624f36d9774719a22987f0daae1e822021-12-02T17:05:48ZSwitching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III10.1038/s42004-021-00473-72399-3669https://doaj.org/article/bd624f36d9774719a22987f0daae1e822021-03-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00473-7https://doaj.org/toc/2399-3669The formation of solid solutions can result in changes of relative stabilities of crystal polymorphs. Here, the elusive form III of benzamide is stabilized through solid solution formation with nicotinamide. It is shown, experimentally and computationally, how such thermodynamic switching allows for consistent and facile crystallization of the otherwise elusive benzamide form III.Weronika KrasAndrea CarlettaRiccardo MontisRachel A. SullivanAurora J. Cruz-CabezaNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Weronika Kras Andrea Carletta Riccardo Montis Rachel A. Sullivan Aurora J. Cruz-Cabeza Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III
description	The formation of solid solutions can result in changes of relative stabilities of crystal polymorphs. Here, the elusive form III of benzamide is stabilized through solid solution formation with nicotinamide. It is shown, experimentally and computationally, how such thermodynamic switching allows for consistent and facile crystallization of the otherwise elusive benzamide form III.
format	article
author	Weronika Kras Andrea Carletta Riccardo Montis Rachel A. Sullivan Aurora J. Cruz-Cabeza
author_facet	Weronika Kras Andrea Carletta Riccardo Montis Rachel A. Sullivan Aurora J. Cruz-Cabeza
author_sort	Weronika Kras
title	Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III
title_short	Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III
title_full	Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III
title_fullStr	Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III
title_full_unstemmed	Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III
title_sort	switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form iii
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd624f36d9774719a22987f0daae1e82
work_keys_str_mv	AT weronikakras switchingpolymorphstabilitieswithimpuritiesprovidesathermodynamicroutetobenzamideformiii AT andreacarletta switchingpolymorphstabilitieswithimpuritiesprovidesathermodynamicroutetobenzamideformiii AT riccardomontis switchingpolymorphstabilitieswithimpuritiesprovidesathermodynamicroutetobenzamideformiii AT rachelasullivan switchingpolymorphstabilitieswithimpuritiesprovidesathermodynamicroutetobenzamideformiii AT aurorajcruzcabeza switchingpolymorphstabilitieswithimpuritiesprovidesathermodynamicroutetobenzamideformiii
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Switching polymorph stabilities with impurities provides a thermodynamic route to benzamide form III

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