Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

The microtubule associated protein Tau also interacts with filamentous actin. Here the authors combine biophysical experiments and NMR studies to characterize the structural changes that occur in Tau upon binding to filamentous actin and show that phosphorylation of serine 262 attenuates actin bindi...

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Main Authors:	Yunior Cabrales Fontela, Harindranath Kadavath, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstetter
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/bd6319513d5748d69c7d46171a874231
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spelling	oai:doaj.org-article:bd6319513d5748d69c7d46171a8742312021-12-02T13:24:33ZMultivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau10.1038/s41467-017-02230-82041-1723https://doaj.org/article/bd6319513d5748d69c7d46171a8742312017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02230-8https://doaj.org/toc/2041-1723The microtubule associated protein Tau also interacts with filamentous actin. Here the authors combine biophysical experiments and NMR studies to characterize the structural changes that occur in Tau upon binding to filamentous actin and show that phosphorylation of serine 262 attenuates actin binding of Tau.Yunior Cabrales FontelaHarindranath KadavathJacek BiernatDietmar RiedelEckhard MandelkowMarkus ZweckstetterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunior Cabrales Fontela Harindranath Kadavath Jacek Biernat Dietmar Riedel Eckhard Mandelkow Markus Zweckstetter Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
description	The microtubule associated protein Tau also interacts with filamentous actin. Here the authors combine biophysical experiments and NMR studies to characterize the structural changes that occur in Tau upon binding to filamentous actin and show that phosphorylation of serine 262 attenuates actin binding of Tau.
format	article
author	Yunior Cabrales Fontela Harindranath Kadavath Jacek Biernat Dietmar Riedel Eckhard Mandelkow Markus Zweckstetter
author_facet	Yunior Cabrales Fontela Harindranath Kadavath Jacek Biernat Dietmar Riedel Eckhard Mandelkow Markus Zweckstetter
author_sort	Yunior Cabrales Fontela
title	Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
title_short	Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
title_full	Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
title_fullStr	Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
title_full_unstemmed	Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
title_sort	multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein tau
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bd6319513d5748d69c7d46171a874231
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Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

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