Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements

Abstract Adaptation of movements involving the proximal and distal upper-limb can be differentially facilitated by anodal transcranial direct current stimulation (TDCS) over the cerebellum and primary motor cortex (M1). Here, we build on this evidence by demonstrating that cathodal TDCS impairs moto...

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Autores principales:	Matthew Weightman, John-Stuart Brittain, R. Chris Miall, Ned Jenkinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd67af4ecf1542d69675018489d66031
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spelling	oai:doaj.org-article:bd67af4ecf1542d69675018489d660312021-12-02T15:54:02ZDirect and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements10.1038/s41598-021-83656-52045-2322https://doaj.org/article/bd67af4ecf1542d69675018489d660312021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83656-5https://doaj.org/toc/2045-2322Abstract Adaptation of movements involving the proximal and distal upper-limb can be differentially facilitated by anodal transcranial direct current stimulation (TDCS) over the cerebellum and primary motor cortex (M1). Here, we build on this evidence by demonstrating that cathodal TDCS impairs motor adaptation with a differentiation of the proximal and distal upper-limbs, relative to the site of stimulation. Healthy young adults received M1 or cerebellar cathodal TDCS while making fast ‘shooting’ movements towards targets under 60° rotated visual feedback conditions, using either whole-arm reaching or fine hand and finger movements. As predicted, we found that cathodal cerebellar TDCS resulted in impairment of adaptation of movements with the whole arm compared to M1 and sham groups, which proved significantly different during late adaptation. However, cathodal cerebellar TDCS also significantly enhanced adaptation of hand movements, which may reflect changes in the excitability of the pathway between the cerebellum and M1. We found no evidence for change of adaptation rates using arm or finger movements following cathodal TDCS directly over M1. These results are further evidence to support movement specific effects of TDCS, and highlight how the connectivity and functional organisation of the cerebellum and M1 must be considered when designing TDCS-based therapies.Matthew WeightmanJohn-Stuart BrittainR. Chris MiallNed JenkinsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew Weightman John-Stuart Brittain R. Chris Miall Ned Jenkinson Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
description	Abstract Adaptation of movements involving the proximal and distal upper-limb can be differentially facilitated by anodal transcranial direct current stimulation (TDCS) over the cerebellum and primary motor cortex (M1). Here, we build on this evidence by demonstrating that cathodal TDCS impairs motor adaptation with a differentiation of the proximal and distal upper-limbs, relative to the site of stimulation. Healthy young adults received M1 or cerebellar cathodal TDCS while making fast ‘shooting’ movements towards targets under 60° rotated visual feedback conditions, using either whole-arm reaching or fine hand and finger movements. As predicted, we found that cathodal cerebellar TDCS resulted in impairment of adaptation of movements with the whole arm compared to M1 and sham groups, which proved significantly different during late adaptation. However, cathodal cerebellar TDCS also significantly enhanced adaptation of hand movements, which may reflect changes in the excitability of the pathway between the cerebellum and M1. We found no evidence for change of adaptation rates using arm or finger movements following cathodal TDCS directly over M1. These results are further evidence to support movement specific effects of TDCS, and highlight how the connectivity and functional organisation of the cerebellum and M1 must be considered when designing TDCS-based therapies.
format	article
author	Matthew Weightman John-Stuart Brittain R. Chris Miall Ned Jenkinson
author_facet	Matthew Weightman John-Stuart Brittain R. Chris Miall Ned Jenkinson
author_sort	Matthew Weightman
title	Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
title_short	Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
title_full	Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
title_fullStr	Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
title_full_unstemmed	Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements
title_sort	direct and indirect effects of cathodal cerebellar tdcs on visuomotor adaptation of hand and arm movements
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd67af4ecf1542d69675018489d66031
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Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements

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