Transient hysteresis and inherent stochasticity in gene regulatory networks

Cell fate commitment is understood in terms of bistable regulatory circuits with hysteresis, but inherent stochasticity in gene expression is incompatible with hysteresis. Here, the authors quantify how, under slow dynamics, the dependency of the non-stationary solutions on the initial state of the...

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Autores principales:	M. Pájaro, I. Otero-Muras, C. Vázquez, A. A. Alonso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd6a08acce10464ea7c443d91d4ea7d5
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spelling	oai:doaj.org-article:bd6a08acce10464ea7c443d91d4ea7d52021-12-02T16:58:03ZTransient hysteresis and inherent stochasticity in gene regulatory networks10.1038/s41467-019-12344-w2041-1723https://doaj.org/article/bd6a08acce10464ea7c443d91d4ea7d52019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12344-whttps://doaj.org/toc/2041-1723Cell fate commitment is understood in terms of bistable regulatory circuits with hysteresis, but inherent stochasticity in gene expression is incompatible with hysteresis. Here, the authors quantify how, under slow dynamics, the dependency of the non-stationary solutions on the initial state of the cells can lead to transient hysteresis.M. PájaroI. Otero-MurasC. VázquezA. A. AlonsoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Pájaro I. Otero-Muras C. Vázquez A. A. Alonso Transient hysteresis and inherent stochasticity in gene regulatory networks
description	Cell fate commitment is understood in terms of bistable regulatory circuits with hysteresis, but inherent stochasticity in gene expression is incompatible with hysteresis. Here, the authors quantify how, under slow dynamics, the dependency of the non-stationary solutions on the initial state of the cells can lead to transient hysteresis.
format	article
author	M. Pájaro I. Otero-Muras C. Vázquez A. A. Alonso
author_facet	M. Pájaro I. Otero-Muras C. Vázquez A. A. Alonso
author_sort	M. Pájaro
title	Transient hysteresis and inherent stochasticity in gene regulatory networks
title_short	Transient hysteresis and inherent stochasticity in gene regulatory networks
title_full	Transient hysteresis and inherent stochasticity in gene regulatory networks
title_fullStr	Transient hysteresis and inherent stochasticity in gene regulatory networks
title_full_unstemmed	Transient hysteresis and inherent stochasticity in gene regulatory networks
title_sort	transient hysteresis and inherent stochasticity in gene regulatory networks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bd6a08acce10464ea7c443d91d4ea7d5
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_version_	1718382412101058560

Transient hysteresis and inherent stochasticity in gene regulatory networks

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