Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease

Three-dimensional (3D) culture systems opened up new horizons in studying the biology of tissues and organs, modelling various diseases, and screening drugs. Producing accurate in vitro models increases the possibilities for studying molecular control of cell–cell and cell–microenvironment interacti...

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Autores principales:	Guya Diletta Marconi, Cristina Porcheri, Oriana Trubiani, Thimios A. Mitsiadis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spheroids organoids organ-on-a-chip microfluidics 3D culture systems Notch signalling Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bd6c8ed8282d4226a65816237f97f42b
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id	oai:doaj.org-article:bd6c8ed8282d4226a65816237f97f42b
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spelling	oai:doaj.org-article:bd6c8ed8282d4226a65816237f97f42b2021-11-25T17:56:58ZThree-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease10.3390/ijms2222124731422-00671661-6596https://doaj.org/article/bd6c8ed8282d4226a65816237f97f42b2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12473https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Three-dimensional (3D) culture systems opened up new horizons in studying the biology of tissues and organs, modelling various diseases, and screening drugs. Producing accurate in vitro models increases the possibilities for studying molecular control of cell–cell and cell–microenvironment interactions in detail. The Notch signalling is linked to cell fate determination, tissue definition, and maintenance in both physiological and pathological conditions. Hence, 3D cultures provide new accessible platforms for studying activation and modulation of the Notch pathway. In this review, we provide an overview of the recent advances in different 3D culture systems, including spheroids, organoids, and “organ-on-a-chip” models, and their use in analysing the crucial role of Notch signalling in the maintenance of tissue homeostasis, pathology, and regeneration.Guya Diletta MarconiCristina PorcheriOriana TrubianiThimios A. MitsiadisMDPI AGarticlespheroidsorganoidsorgan-on-a-chipmicrofluidics3D culture systemsNotch signallingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12473, p 12473 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spheroids organoids organ-on-a-chip microfluidics 3D culture systems Notch signalling Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	spheroids organoids organ-on-a-chip microfluidics 3D culture systems Notch signalling Biology (General) QH301-705.5 Chemistry QD1-999 Guya Diletta Marconi Cristina Porcheri Oriana Trubiani Thimios A. Mitsiadis Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
description	Three-dimensional (3D) culture systems opened up new horizons in studying the biology of tissues and organs, modelling various diseases, and screening drugs. Producing accurate in vitro models increases the possibilities for studying molecular control of cell–cell and cell–microenvironment interactions in detail. The Notch signalling is linked to cell fate determination, tissue definition, and maintenance in both physiological and pathological conditions. Hence, 3D cultures provide new accessible platforms for studying activation and modulation of the Notch pathway. In this review, we provide an overview of the recent advances in different 3D culture systems, including spheroids, organoids, and “organ-on-a-chip” models, and their use in analysing the crucial role of Notch signalling in the maintenance of tissue homeostasis, pathology, and regeneration.
format	article
author	Guya Diletta Marconi Cristina Porcheri Oriana Trubiani Thimios A. Mitsiadis
author_facet	Guya Diletta Marconi Cristina Porcheri Oriana Trubiani Thimios A. Mitsiadis
author_sort	Guya Diletta Marconi
title	Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
title_short	Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
title_full	Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
title_fullStr	Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
title_full_unstemmed	Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease
title_sort	three-dimensional culture systems for dissecting notch signalling in health and disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bd6c8ed8282d4226a65816237f97f42b
work_keys_str_mv	AT guyadilettamarconi threedimensionalculturesystemsfordissectingnotchsignallinginhealthanddisease AT cristinaporcheri threedimensionalculturesystemsfordissectingnotchsignallinginhealthanddisease AT orianatrubiani threedimensionalculturesystemsfordissectingnotchsignallinginhealthanddisease AT thimiosamitsiadis threedimensionalculturesystemsfordissectingnotchsignallinginhealthanddisease
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Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease

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