Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

Here, Proto et al. show that human infective Plasmodium falciparum isolates contain an inactivating mutation in the erythrocyte invasion associated gene PfEBA165, while homologues of ape-infective Laverania species are intact, and that expression of intact PfEBA165 is incompatible with parasite grow...

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Autores principales:	William R. Proto, Sasha V. Siegel, Selasi Dankwa, Weimin Liu, Alison Kemp, Sarah Marsden, Zenon A. Zenonos, Steve Unwin, Paul M. Sharp, Gavin J. Wright, Beatrice H. Hahn, Manoj T. Duraisingh, Julian C. Rayner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba
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spelling	oai:doaj.org-article:bd6dae0de5d54fc5a18cf05d76370dba2021-12-02T14:38:44ZAdaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand10.1038/s41467-019-12294-32041-1723https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12294-3https://doaj.org/toc/2041-1723Here, Proto et al. show that human infective Plasmodium falciparum isolates contain an inactivating mutation in the erythrocyte invasion associated gene PfEBA165, while homologues of ape-infective Laverania species are intact, and that expression of intact PfEBA165 is incompatible with parasite growth in human erythrocytes.William R. ProtoSasha V. SiegelSelasi DankwaWeimin LiuAlison KempSarah MarsdenZenon A. ZenonosSteve UnwinPaul M. SharpGavin J. WrightBeatrice H. HahnManoj T. DuraisinghJulian C. RaynerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William R. Proto Sasha V. Siegel Selasi Dankwa Weimin Liu Alison Kemp Sarah Marsden Zenon A. Zenonos Steve Unwin Paul M. Sharp Gavin J. Wright Beatrice H. Hahn Manoj T. Duraisingh Julian C. Rayner Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
description	Here, Proto et al. show that human infective Plasmodium falciparum isolates contain an inactivating mutation in the erythrocyte invasion associated gene PfEBA165, while homologues of ape-infective Laverania species are intact, and that expression of intact PfEBA165 is incompatible with parasite growth in human erythrocytes.
format	article
author	William R. Proto Sasha V. Siegel Selasi Dankwa Weimin Liu Alison Kemp Sarah Marsden Zenon A. Zenonos Steve Unwin Paul M. Sharp Gavin J. Wright Beatrice H. Hahn Manoj T. Duraisingh Julian C. Rayner
author_facet	William R. Proto Sasha V. Siegel Selasi Dankwa Weimin Liu Alison Kemp Sarah Marsden Zenon A. Zenonos Steve Unwin Paul M. Sharp Gavin J. Wright Beatrice H. Hahn Manoj T. Duraisingh Julian C. Rayner
author_sort	William R. Proto
title	Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
title_short	Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
title_full	Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
title_fullStr	Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
title_full_unstemmed	Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
title_sort	adaptation of plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bd6dae0de5d54fc5a18cf05d76370dba
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Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand

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