High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population
Guo-bao Hong,1,2 Pei-chun Gao,1,3 Yun-yin Chen,1 Yue Xia,1 Xiao-su Ke,1 Xiao-fei Shao,1 Chong-xiang Xiong,1 Hai-shan Chen,1 Hua Xiao,1 Jing Ning,1 He-qun Zou1 1Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guan...
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Dove Medical Press
2020
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oai:doaj.org-article:bd7949d592504ab0a39f8faab239ea262021-12-02T10:46:14ZHigh-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population1178-7007https://doaj.org/article/bd7949d592504ab0a39f8faab239ea262020-02-01T00:00:00Zhttps://www.dovepress.com/high-sensitivity-c-reactive-protein-leads-to-increased-incident-metabo-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Guo-bao Hong,1,2 Pei-chun Gao,1,3 Yun-yin Chen,1 Yue Xia,1 Xiao-su Ke,1 Xiao-fei Shao,1 Chong-xiang Xiong,1 Hai-shan Chen,1 Hua Xiao,1 Jing Ning,1 He-qun Zou1 1Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, People’s Republic of China; 2Department of Nephrology, The Affiliated Nanhai Hospital of Southern Medical University, Foshan 528200, People’s Republic of China; 3School of Public Health, Southern Medical University, Guangzhou, Guangdong 510630, People’s Republic of ChinaCorrespondence: He-qun ZouDepartment of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, People’s Republic of ChinaTel +86-20-6278-4391Email hequnzou@hotmail.comPurpose: Metabolic syndrome (MetS), characterized by a constellation of insulin resistance, central obesity, hypertension, and hyperlipidemia, is a global health threat. High-sensitivity C-reactive protein (hs-CRP) has been shown to be associated with type 2 diabetes and cardiovascular disease; however, its association with incident MetS is less known. Therefore, the aim of this study was to examine the prospective association between hs-CRP and MetS among a Chinese population in a 5-year follow-up study.Patients and Methods: The levels of hs-CRP were measured using serum samples collected at baseline recruitment in 2012 from 886 participants without MetS. Follow-up interviews were conducted in 2018, and MetS was diagnosed by 2017 criteria from the Chinese Diabetes Society. Multivariate logistic regression models were used to assess the overall and sex-specific associations between hs-CRP and incident MetS. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were computed with adjustment for demographic, socioeconomic, clinical, and lifestyle factors.Results: After a mean follow-up duration of 5.40 ± 0.56 years, 116 (13.3%) participants developed MetS. In the total study population, increased hs-CRP levels were associated with a higher risk of MetS (OR comparing extreme quartiles of hs-CRP: 4.06 [95% CI: 1.91– 8.65]) in the fully-adjusted model. When stratified by sex, the positive association was only observed in women (OR: 4.82 [1.89– 12.3]) but not in men (OR: 3.15 [0.82– 12.1]; P-interaction = 0.039).Conclusion: In this study of a Chinese population, a positive association between hs-CRP and incident MetS was found only in women and not in men. Sex-specific prediction and intervention of MetS using hs-CRP as a target should be further evaluated.Keywords: inflammation, high-sensitivity C-reactive protein, metabolic syndrome, cohort study, follow upHong GGao PChen YXia YKe XShao XXiong CChen HXiao HNing JZou HDove Medical Pressarticleinflammationhigh-sensitivity c-reactive proteinmetabolic syndromecohort studyfollow up.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 581-590 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
inflammation high-sensitivity c-reactive protein metabolic syndrome cohort study follow up. Specialties of internal medicine RC581-951 |
| spellingShingle |
inflammation high-sensitivity c-reactive protein metabolic syndrome cohort study follow up. Specialties of internal medicine RC581-951 Hong G Gao P Chen Y Xia Y Ke X Shao X Xiong C Chen H Xiao H Ning J Zou H High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population |
| description |
Guo-bao Hong,1,2 Pei-chun Gao,1,3 Yun-yin Chen,1 Yue Xia,1 Xiao-su Ke,1 Xiao-fei Shao,1 Chong-xiang Xiong,1 Hai-shan Chen,1 Hua Xiao,1 Jing Ning,1 He-qun Zou1 1Department of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, People’s Republic of China; 2Department of Nephrology, The Affiliated Nanhai Hospital of Southern Medical University, Foshan 528200, People’s Republic of China; 3School of Public Health, Southern Medical University, Guangzhou, Guangdong 510630, People’s Republic of ChinaCorrespondence: He-qun ZouDepartment of Nephrology, Institute of Nephrology and Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, People’s Republic of ChinaTel +86-20-6278-4391Email hequnzou@hotmail.comPurpose: Metabolic syndrome (MetS), characterized by a constellation of insulin resistance, central obesity, hypertension, and hyperlipidemia, is a global health threat. High-sensitivity C-reactive protein (hs-CRP) has been shown to be associated with type 2 diabetes and cardiovascular disease; however, its association with incident MetS is less known. Therefore, the aim of this study was to examine the prospective association between hs-CRP and MetS among a Chinese population in a 5-year follow-up study.Patients and Methods: The levels of hs-CRP were measured using serum samples collected at baseline recruitment in 2012 from 886 participants without MetS. Follow-up interviews were conducted in 2018, and MetS was diagnosed by 2017 criteria from the Chinese Diabetes Society. Multivariate logistic regression models were used to assess the overall and sex-specific associations between hs-CRP and incident MetS. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were computed with adjustment for demographic, socioeconomic, clinical, and lifestyle factors.Results: After a mean follow-up duration of 5.40 ± 0.56 years, 116 (13.3%) participants developed MetS. In the total study population, increased hs-CRP levels were associated with a higher risk of MetS (OR comparing extreme quartiles of hs-CRP: 4.06 [95% CI: 1.91– 8.65]) in the fully-adjusted model. When stratified by sex, the positive association was only observed in women (OR: 4.82 [1.89– 12.3]) but not in men (OR: 3.15 [0.82– 12.1]; P-interaction = 0.039).Conclusion: In this study of a Chinese population, a positive association between hs-CRP and incident MetS was found only in women and not in men. Sex-specific prediction and intervention of MetS using hs-CRP as a target should be further evaluated.Keywords: inflammation, high-sensitivity C-reactive protein, metabolic syndrome, cohort study, follow up |
| format |
article |
| author |
Hong G Gao P Chen Y Xia Y Ke X Shao X Xiong C Chen H Xiao H Ning J Zou H |
| author_facet |
Hong G Gao P Chen Y Xia Y Ke X Shao X Xiong C Chen H Xiao H Ning J Zou H |
| author_sort |
Hong G |
| title |
High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population |
| title_short |
High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population |
| title_full |
High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population |
| title_fullStr |
High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population |
| title_full_unstemmed |
High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population |
| title_sort |
high-sensitivity c-reactive protein leads to increased incident metabolic syndrome in women but not in men: a five-year follow-up study in a chinese population |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/bd7949d592504ab0a39f8faab239ea26 |
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